Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed, newly diagnosed, high-risk epithelial
tumors of mullerian origin, including: Ovarian epithelial cancer Peritoneal papillary
serous cancer Primary fallopian tube cancer Endometrial cancer High-risk is defined as:
Any amount of gross residual disease remaining at the time of initial debulking surgery
AND/OR Any radiographic or physical exam evidence of disease after surgery AND/OR Disease
outside of the abdomen (e.g., malignant pleural effusion) AND/OR Parenchymal liver,
spleen, or lung metastases

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy:
More than 2 months Hematopoietic: WBC at least 3,000/mm3 Absolute neutrophil count at
least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than
upper limit of normal (ULN) Alkaline phosphatase no greater than 2.5 times ULN SGOT and
SGPT no greater than 1.5 times ULN Renal: Creatinine no greater than 1.5 mg/dL Creatinine
clearance at least 35 mL/min Cardiovascular: Acceptable cardiac exam No active cardiac
ischemia Pulmonary: Acceptable pulmonary exam No active pulmonary infection or compromise
Other: Not pregnant or nursing No peripheral neuropathy grade 2 or greater No other
debilitating medical or psychiatric conditions that would preclude study No other
malignancy within the past 3 years except limited stage basal or squamous cell skin cancer
or carcinoma in situ of the cervix No evidence of infection Adequate bowel function, oral
intake, and wound healing ability

PRIOR CONCURRENT THERAPY: Biologic therapy: No prior cytokine therapy for epithelial
tumors of mullerian origin Chemotherapy: No more than 1 prior chemotherapy regimen for
epithelial tumors of mullerian origin At least 3 years since other prior chemotherapy
Endocrine therapy: Not specified Radiotherapy: No prior pelvic radiotherapy Surgery: See
Disease Characteristics At least 7 days since prior surgery