An Evaluation of the Effect of Androgen Ablation on Bone Resorption in Prostate Cancer Patients
- Evaluate the effect of androgen ablation on bone resorption in patients with or without
bone metastases secondary to prostate cancer.
OUTLINE: Patients are stratified according to prior androgen ablation therapy (yes vs no)
and metastatic disease (yes vs no).
Patients undergo blood work and 24 hour urine collection on day 1 and at week 6-8. Patients
who have received androgen ablation therapy and are found to have increased bone resorption
undergo a dual energy x-ray absorptiometry (DEXA) scan.
A comparison is made between androgen ablation therapy and bone resorption and if metastases
are associated with the two.
PROJECTED ACCRUAL: A total of 150 patients will be accrued for this study within 9 months.
Primary Purpose: Supportive Care
Deepak M. Sahasrabudhe, MD
James P. Wilmot Cancer Center
United States: Federal Government
|James P. Wilmot Cancer Center||Rochester, New York 14642|