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A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, and Radiotherapy Versus 5-Fluorouracil, Cisplatin, and Radiotherapy in Carcinoma of the Anal Canal

Phase 3
18 Years
Not Enrolling
Anal Cancer

Thank you

Trial Information

A Phase III Randomized Study of 5-Fluorouracil, Mitomycin-C, and Radiotherapy Versus 5-Fluorouracil, Cisplatin, and Radiotherapy in Carcinoma of the Anal Canal


- Compare the initial and total local and distant failure rates in patients with anal
canal cancer treated with either fluorouracil (5-FU) plus mitomycin concurrently with
radiotherapy or 5-FU plus cisplatin followed by 5-FU plus cisplatin concurrently with

- Identify any differences in local control and colostomy rates at 2 years in patients
treated with these regimens.

- Determine any difference in colostomy free, disease free, or overall survival in
patients treated with these regimens.

- Compare the toxic effects of these regimens in these patients.

- Evaluate the prognostic effects of tumor markers P53 overexpression, human papilloma
virus status, and enzyme HAP1 in patients treated with these regimens.

OUTLINE: This is a randomized study. Patients are stratified according to gender, nodal
status (positive vs negative), and primary tumor size (greater than 2 cm to 5 cm vs greater
than 5 cm). Patients are randomized to 1 of 2 treatment arms.

- Arm I: Patients receive fluorouracil (5-FU) IV continuously over 96 hours beginning on
days 1 and 29 and mitomycin IV on days 1 and 29 with concurrent radiotherapy.

- Arm II: Patients receive induction chemotherapy comprising 5-FU IV continuously over 96
hours beginning on days 1, 29, 57, and 85 and cisplatin IV over 1 hour on days 1, 29,
57, and 85. Beginning on day 57, patients receive concurrent radiotherapy.

In both arms, radiotherapy is administered daily, 5 days a week, for 5-6.5 weeks. Patients
with T3, T4, or N+ lesions or T2 lesions with residual disease receive additional
radiotherapy to a reduced field.

Patients are followed every 3 months for 1 year, every 6 months for 1 year, and then
annually thereafter.

PROJECTED ACCRUAL: A total of 650 patients will be accrued for this study within 5 years.

Inclusion Criteria


- Histologically confirmed primary squamous, basaloid, or cloacogenic carcinoma of the
anal canal, other than carcinoma in situ

- T2-4, Any N, M0 (stage II or III)

- No local or regional recurrence after local excision or abdominal peritoneal



- 18 and over

Performance status:

- Karnofsky 60-100%

Life expectancy:

- Not specified


- WBC at least 4,000/mm^3

- Absolute neutrophil count at least 1,800/mm^3

- Platelet count at least 100,000/mm^3

- Hemoglobin at least 10 g/dL


- Bilirubin less than 1.4 mg/dL


- Creatinine no greater than 1.5 mg/dL OR

- Creatinine clearance at least 80 mL/min


- No uncompensated heart disease

- No uncontrolled high blood pressure



- No active systemic infection

- No uncontrolled diabetes

- No other prior malignancy within the past 5 years except nonmelanoma skin cancer

- No mental condition that would preclude study participation

- Not pregnant or nursing

- Fertile patients must use effective contraception


Biologic therapy:

- Prior epoetin alfa allowed in lieu of blood transfusions


- At least 5 years since prior chemotherapy

Endocrine therapy:

- Not specified


- At least 5 years since prior radiotherapy


- No prior surgery of anal canal except for biopsy of study site

Type of Study:


Study Design:

Allocation: Randomized, Primary Purpose: Treatment

Principal Investigator

Jaffer A. Ajani, MD

Investigator Role:

Study Chair

Investigator Affiliation:

M.D. Anderson Cancer Center


United States: Federal Government

Study ID:




Start Date:

October 1998

Completion Date:

Related Keywords:

  • Anal Cancer
  • stage II anal cancer
  • stage III anal cancer
  • squamous cell carcinoma of the anus
  • cloacogenic carcinoma of the anus
  • basaloid carcinoma of the anus
  • Anus Neoplasms



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Methodist Medical Center of Illinois Peoria, Illinois  61636
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Albert Einstein Cancer Center Philadelphia, Pennsylvania  19141
Mercy Hospital of Pittsburgh Pittsburgh, Pennsylvania  15219
Reading Hospital and Medical Center Reading, Pennsylvania  19612-6052
Mercy Hospital Cancer Center - Scranton Scranton, Pennsylvania  18501
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CCOP - Greenville Greenville, South Carolina  29615
Harrington Cancer Center Amarillo, Texas  79106
Joe Arrington Cancer Research and Treatment Center Lubbock, Texas  79410-1894
Dixie Regional Medical Center Saint George, Utah  84770
LDS Hospital Salt Lake City, Utah  84143
St. Vincent Hospital Green Bay, Wisconsin  54307-3508
University of Wisconsin Comprehensive Cancer Center Madison, Wisconsin  53792
Community Memorial Hospital Menomonee Falls, Wisconsin  53051
Veterans Affairs Medical Center - Milwaukee (Zablocki) Milwaukee, Wisconsin  53295
University of Miami Sylvester Comprehensive Cancer Center Miami, Florida  33136
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Holden Comprehensive Cancer Center at University of Iowa Iowa City, Iowa  52242-1002
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Siteman Cancer Center at Barnes-Jewish Hospital Saint Louis, Missouri  63110
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Cancer Institute of New Jersey at the Cooper University Hospital Camden, New Jersey  08103-1489
MetroHealth's Cancer Care Center at MetroHealth Medical Center Cleveland, Ohio  44106
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Columbus, Ohio  43210-1240
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Kimmel Cancer Center at Thomas Jefferson University - Philadelphia Philadelphia, Pennsylvania  19107
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland  21231-2410
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Madigan Army Medical Center Tacoma, Washington  98431-5048
Naval Medical Center - San Diego San Diego, California  92134-3202
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. Syracuse, New York  13217
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Camden-Clark Memorial Hospital Parkersburg, West Virginia  26102
Providence Alaska Medical Center Anchorage, Alaska  99508
Foundation for Cancer Research and Education Phoenix, Arizona  85013
Monmouth Medical Center Long Branch, New Jersey  07740-6395
Veterans Affairs Medical Center - Syracuse Syracuse, New York  13210
University of California Davis Cancer Center Sacramento, California  95817
Wesley Medical Center Wichita, Kansas  67214
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts  02115
University of New Mexico Cancer Research and Treatment Center Albuquerque, New Mexico  87131
City of Hope Comprehensive Cancer Center Duarte, California  91010
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Mobile Infirmary Medical Center Mobile, Alabama  36640-0460
John Stoddard Cancer Center at Iowa Methodist Medical Center Des Moines, Iowa  50309
Midlands Cancer Center at Midlands Community Hospital Papillion, Nebraska  68128-4157
Sunrise Hospital and Medical Center Las Vegas, Nevada  89109-2306
St. Vincent Mercy Medical Center Toledo, Ohio  43608
CCOP - Colorado Cancer Research Program, Incorporated Denver, Colorado  80224
Great Falls Clinic Great Falls, Montana  59405
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Kansas City, Kansas  66160-7353
Markey Cancer Center at University of Kentucky Chandler Medical Center Lexington, Kentucky  40536-0084
Cancer Research Center at Boston Medical Center Boston, Massachusetts  02118
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Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Seattle, Washington  98104
Blumenthal Cancer Center at Carolinas Medical Center Charlotte, North Carolina  28232-2861
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Fairview University Medical Center - University Campus Minneapolis, Minnesota  55455
Hulston Cancer Center at Cox Medical Center South Springfield, Missouri  65807
St. John's Regional Health Center Springfield, Missouri  65804
SUNY Downstate Medical Center Brooklyn, New York  11203
McDowell Cancer Center at Akron General Medical Center Akron, Ohio  44307
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University Cleveland, Ohio  44106
Sioux Valley Hospital and University of South Dakota Medical Center Sioux Falls, South Dakota  57117-5134
M.D. Anderson Cancer Center at University of Texas Houston, Texas  77030
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Trinity Cancer Care Center Minot, North Dakota  58701
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St. Luke's Hospital Cancer Center Bethlehem, Pennsylvania  18015
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Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha Omaha, Nebraska  68114-4199
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James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester, New York  14642
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Mount Nittany Medical Center State College, Pennsylvania  16803
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Bay Area Cancer Care Center at Bay Area Medical Center Marinette, Wisconsin  54143
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21st Century Oncology - Fort Myers Fort Myers, Florida  33901-8082
Tallahassee Memorial Hospital Tallahassee, Florida  32308
Baptist Cancer Institute - Jacksonville Jacksonville, Florida  32207
Saint Anthony's Hospital at Saint Anthony's Health Center Alton, Illinois  62002
Siouxland Hematology-Oncology Associates Sioux City, Iowa  51101
Cancer Center of Kansas - Chanute Chanute, Kansas  66720
Cancer Center of Kansas - Dodge City Dodge City, Kansas  67801
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Cancer Center of Kansas - Kingman Kingman, Kansas  67068
Southwest Medical Center Liberal, Kansas  67901
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Pratt Cancer Center of Kansas Pratt, Kansas  67124
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Cancer Center of Kansas, P.A. Wichita, Kansas  67208
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Metropolitan Hospital Grand Rapids, Michigan  49506
Lacks Cancer Center at Saint Mary's Mercy Medical Center Grand Rapids, Michigan  49503
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Northern Michigan Hospital Petoskey, Michigan  49770
Munson Medical Center Traverse City, Michigan  49684
St. Francis Medical Center Cape Girardeau, Missouri  63701
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David C. Pratt Cancer Center at St. John's Mercy St. Louis, Missouri  63141
Sletten Regional Cancer Institute Great Falls, Montana  59405
Fox Chase Virtua Health Cancer Program - Marlton Marlton, New Jersey  08053
Wayne Memorial Hospital, Incorporated Goldsboro, North Carolina  27534
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Doctors Hospital at Ohio Health Columbus, Ohio  43228
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Grant Riverside Cancer Services Columbus, Ohio  43215
Mount Carmel West Hospital Columbus, Ohio  43222
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Fairfield Medical Center Lancaster, Ohio  43130
Strecker Cancer Center at Marietta Memorial Hospital Marietta, Ohio  45750
Licking Memorial Cancer Care Program at Licking Memorial Hospital Newark, Ohio  43055
Community Hospital of Springfield and Clark County Springfield, Ohio  45505
Mercy Medical Center Oncology Unit Springfield, Ohio  45504
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Genesis - Good Samaritan Hospital Zanesville, Ohio  43701
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Medical X-Ray Center Sioux Falls, South Dakota  57105
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Olympic Hematology and Oncology Bremerton, Washington  98310
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Harborview Medical Center Seattle, Washington  98104
Group Health Central Hospital Seattle, Washington  98104
Cancer Care Northwest - Spokane South Spokane, Washington  99202
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Mountain States Tumor Institute - Boise Boise, Idaho  83712
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University Medical Center of Southern Nevada Las Vegas, Nevada  89102
Finger Lakes Hematology and Oncology Clifton Springs, New York  14432
Joan Karnell Cancer Center at Pennsylvania Hospital Philadelphia, Pennsylvania  19107
Alta Bates Comprehensive Cancer Center Berkeley, California  94704
Mount Diablo Regional Cancer Center Concord, California  94524-4110
Marin Cancer Institute at Marin General Hospital Greenbrae, California  94904
Saint Rose Hospital Hayward, California  94545
Memorial Medical Center Cancer Services Modesto, California  95355
California Pacific Medical Center - California Campus San Francisco, California  94118
J.C. Robinson, M.D. Regional Cancer Center San Pablo, California  94806
Sutter Solano Medical Center Vallejo, California  94589
St. Mary-Corwin Regional Medical Center Pueblo, Colorado  81004
Beebe Medical Center Lewes, Delaware  19958
St. Francis Hospital Wilmington, Delaware  19805
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Fort Lauderdale, Florida  33308
Ella Milbank Foshay Cancer Center at Jupiter Medical Center Jupiter, Florida  33458
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Boise, Idaho  83706
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Graham Hospital Canton, Illinois  61520
Memorial Hospital Carthage, Illinois  62321
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Galesburg Clinic Galesburg, Illinois  61401
InterCommunity Cancer Center of Western Illinois Galesburg, Illinois  61401
Mason District Hospital Havana, Illinois  62644
Hopedale Medical Complex Hopedale, Illinois  61747
Kewanee Hospital Kewanee, Illinois  61443
McDonough District Hospital Macomb, Illinois  61455
Edward Hospital Cancer Center Naperville, Illinois  60540
BroMenn Regional Medical Center Normal, Illinois  61761
Community Cancer Center Normal, Illinois  61761
Community Hospital of Ottawa Ottawa, Illinois  61350
Cancer Treatment Center at Pekin Hospital Pekin, Illinois  61554
OSF St. Francis Medical Center Peoria, Illinois  61637
Proctor Hospital Peoria, Illinois  61614
Illinois Valley Community Hospital Peru, Illinois  61354
Perry Memorial Hospital Princeton, Illinois  61356
St. Margaret's Hospital Spring Valley, Illinois  61362
Valley Cancer Center Spring Valley, Illinois  61362
Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte, Indiana  46350
St. Luke's Hospital Cedar Rapids, Iowa  52402
Genesis Medical Center - West Campus Davenport, Iowa  52804
Genesis Regional Cancer Center at Genesis Medical Center Davenport, Iowa  52803
John Stoddard Cancer Center at Iowa Lutheran Hospital Des Moines, Iowa  50316-2301
Mercy Capitol Hospital Des Moines, Iowa  50307
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Des Moines, Iowa  50309
Medical Oncology and Hematology Associates at Mercy Cancer Center Des Moines, Iowa  50314
Mercy Cancer Center at Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Burgess Health Center Onawa, Iowa  51040
Medical Oncology and Hematology Associates - West Des Moines West Des Moines, Iowa  50266
Louisiana State University Health Sciences Center - Monroe Monroe, Louisiana  71210
Feist-Weiller Cancer Center at Louisiana State University Health Sciences Shreveport, Louisiana  71130-3932
Union Hospital Cancer Center at Union Hospital Elkton MD, Maryland  21921
Hickman Cancer Center at Bixby Medical Center Adrian, Michigan  49221
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital Ann Arbor, Michigan  48106-0995
Upper Michigan Cancer Center at Marquette General Hospital Marquette, Michigan  49855
Providence Cancer Institute at Providence Hospital - Southfield Campus Southfield, Michigan  48075
MeritCare Clinic - Bemidji Bemidji, Minnesota  56601
Brainerd Medical Center Brainerd, Minnesota  56401
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital Minneapolis, Minnesota  55407
Chippewa County - Montevideo Hospital Montevideo, Minnesota  56265
Hubert H. Humphrey Cancer Center at North Memorial Medical Center Robbinsdale, Minnesota  55422-2900
CentraCare Clinic - River Campus St. Cloud, Minnesota  56303
Bryan LGH Medical Center West Lincoln, Nebraska  68502
St. Elizabeth Regional Medical Center Lincoln, Nebraska  68510
Booker Cancer Center at Riverview Medical Center Red Bank, New Jersey  07701
Fox Chase Cancer Center at St. Francis Medical Center Trenton, New Jersey  08629
Highland Hospital of Rochester Rochester, New York  14620
Community General Hospital of Greater Syracuse Syracuse, New York  13215
Wayne Radiation Oncology Goldsboro, North Carolina  27534
Wilson Medical Center Wilson, North Carolina  27893-3428
Forsyth Regional Cancer Center at Forsyth Medical Center Winston-Salem, North Carolina  27103
Bismarck Cancer Center Bismarck, North Dakota  58501
St. Alexius Medical Center Bismarck, North Dakota  58502
MeritCare Medical Group Fargo, North Dakota  58122
Samaritan North Cancer Care Center Dayton, Ohio  45415
Grandview Hospital Dayton, Ohio  45405
Good Samaritan Hospital Dayton, Ohio  45406
Charles F. Kettering Memorial Hospital Kettering, Ohio  45429
Lima Memorial Hospital Lima, Ohio  45804
St. Luke's Hospital Maumee, Ohio  43537
Middletown Regional Hospital Middletown, Ohio  45044
St. Charles Mercy Hospital Oregon, Ohio  43616
Firelands Regional Medical Center Sandusky, Ohio  44870
Promedica Cancer Center at Flower Hospital Sylvania, Ohio  43560
Mercy Hospital of Tiffin Tiffin, Ohio  44883
UVMC Cancer Care Center at Upper Valley Medical Center Troy, Ohio  45373-1300
Ruth G. McMillan Cancer Center at Greene Memorial Hospital Xenia, Ohio  45385
Legacy Mount Hood Medical Center Gresham, Oregon  97030
Providence Milwaukie Hospital Milwaukie, Oregon  97222
Kaiser Permanente Health Care - Portland Portland, Oregon  97232
Providence Cancer Center at Providence Portland Medical Center Portland, Oregon  97213-2967
Providence St. Vincent Medical Center Portland, Oregon  97225
Legacy Meridian Park Hospital Tualatin, Oregon  97062
Bryn Mawr Hospital Bryn Mawr, Pennsylvania  19010
Delaware County Regional Cancer Center at Delaware County Memorial Hospital Drexel Hill, Pennsylvania  19026
St. Mary Regional Cancer Center Langhorne, Pennsylvania  19047
Lankenau Cancer Center at Lankenau Hospital Wynnewood, Pennsylvania  19096
Bon Secours St. Francis Health System Greenville, South Carolina  29601
Cancer Therapy and Research Center San Antonio, Texas  78229
University Hospital - San Antonio San Antonio, Texas  78229
Mountainview Medical Berlin, Vermont  05602
Danville Regional Medical Center Danville, Virginia  24541
Virginia Oncology Associates - Hampton Hampton, Virginia  23666
Green Bay Oncology, Limited at St. Vincent Hospital Green Bay, Wisconsin  54301-3526
Eureka Hospital Eureka, Illinois  61530
Joliet Oncology Hematology Associates, Limited - West Joliet, Illinois  60435
Oncology Hematology Associates of Central Illinois - Ottawa Ottawa, Illinois  61350
Cancer Center of Kansas - Ottawa Ottawa, Kansas  66067
DeCesaris Cancer Institute at Anne Arundel Medical Center Annapolis, Maryland  21401
Mercy Hospital Coon Rapids, Minnesota  55433
Mercy and Unity Cancer Center at Mercy and Unity Hospitals Fridley, Minnesota  55432-2799
Park Nicollet Clinic St. Louis Park, Minnesota  55416
St. Anthony's Memorial Hospital Effingham, Illinois  62401
McFarland Clinic, P.C. Ames, Iowa  50010
Saint Anthony Regional Hospital Carroll, Iowa  51401
Miller-Dwan Medical Center Duluth, Minnesota  55805
St. John's Hospital Maplewood, Minnesota  55109
Rice Memorial Hospital Willmar, Minnesota  56201
Fremont Area Medical Center Fremont, Nebraska  68025-2387
Alegent Health - Immanuel Medical Center Omaha, Nebraska  68122
Mid Dakota Clinic, P.C. Bismarck, North Dakota  58501
Pottstown Memorial Regional Cancer Center Pottstown, Pennsylvania  19464
Geisinger Medical Group State College, Pennsylvania  16801
Geisinger Wyoming Valley Medical Center Wilkes-Barre, Pennsylvania  18711
Alaska Regional Hospital Anchorage, Alaska  99508
CCOP - Mayo Clinic Scottsdale Oncology Program Scottsdale, Arizona  85259
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center Ft. Smith, Arkansas  72903
Mills-Peninsula Health Services Burlingame, California  94010
California Cancer Center - Woodward Park Office Fresno, California  93720
Valley Memorial Hospital Livermore, California  94550
Providence Holy Cross Cancer Center Mission Hills, California  91346-9600
Leavey Cancer Center at Northridge Hospital Medical Center Northridge, California  91325
Highland General Hospital Oakland, California  94602
Palo Alto Medical Foundation Palo Alto, California  94301
Pomona Valley Hospital Medical Center Pomona, California  91767
Radiological Associates of Sacramento Medical Group, Inc. Sacramento, California  95815
Middlesex Hospital Cancer Center Middletown, Connecticut  06457
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida Tampa, Florida  33612
Northeast Georgia Medical Center Gainesville, Georgia  30501
Pearlman Comprehensive Cancer Center at South Georgia Medical Center Valdosta, Georgia  31603
Good Shepherd Hospital Barrington, Illinois  60010
Creticos Cancer Center at Advocate Illinois Masonic Medical Center Chicago, Illinois  60657
Cancer Care Center at Advocate Good Samaritan Hospital Downers Grove, Illinois  60515
Swedish American Hospital Rockford, Illinois  61104
St. Francis Hospital and Health Centers Beech Grove, Indiana  46107
Cancer Center at Ball Memorial Hospital Muncie, Indiana  47303
Saint Joseph Regional Medical Center - Plymouth Campus Plymouth, Indiana  46544
Union Hospital Terre Haute, Indiana  47804
Mercy Cancer Center at Mercy Medical Center Cedar Rapids, Iowa  52403
Alegent Health Mercy Hospital Council Bluffs, Iowa  51503
Wendt Regional Cancer Center at Finley Hospital Dubuque, Iowa  52001
Mercy Cancer Center at Mercy Medical Center - North Iowa Mason City, Iowa  50401
Alegent Health Community Memorial Hospital Missouri Valley, Iowa  51555
South Central Kansas Regional Medical Center Arkansas City, Kansas  67005
Cancer Treatment Center at the Medical Center - Bowling Green Bowling Green, Kentucky  42101
Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County Madisonville, Kentucky  42431
Tulane Cancer Center New Orleans, Louisiana  70112
Central Maine Medical Center Lewiston, Maine  04240
Maine General Medical Center - Waterville Waterville, Maine  04901
Bethke Cancer Center at Emerson Hospital Concord, Massachusetts  01742
Hudner Oncology Center at Saint Anne's Hospital Fall River, Massachusetts  02721
Newton - Wellesley Hospital Newton, Massachusetts  02162
South Suburban Oncology Center Quincy, Massachusetts  02169
Battle Creek Health System Battle Creek, Michigan  49017
Great Lakes Cancer Institute at McLaren Regional Medical Center Flint, Michigan  48532
Spectrum Health Hospital - Blodgett Campus Grand Rapids, Michigan  49506
Mercy Hospital Port Huron, Michigan  48060
Oncology Care Associates, P.L.L.C. Saint Joseph, Michigan  49085
Cancer Care Center at St. Luke's Hospital Duluth, Minnesota  55805
Cancer Care Center at Regions Hospital Saint Paul, Minnesota  55101
Saint Francis Cancer Center Shakopee, Minnesota  55379
St. Joseph's Hospital St Paul, Minnesota  55102
Adult and Pediatric Urology, P.L.L.P. St. Cloud, Minnesota  56303
Woodwinds Hospital Woodbury, Minnesota  55125
Regional Cancer Center at Singing River Hospital Pascagoula, Mississippi  39581
Saint Luke's Hospital Chesterfield, Missouri  63017
Missouri Cancer Associates Columbia, Missouri  65201
Missouri Baptist Cancer Center St. Louis, Missouri  63131
Center for Cancer Care and Research St. Louis, Missouri  63141
Cancer Center at the Good Samaritan Health Systems Kearney, Nebraska  68847
Cancer Resource Center - Lincoln Lincoln, Nebraska  68510
Cancer Center at Creighton University Medical Center Omaha, Nebraska  68131
Washoe Cancer Services at Washoe Medical Center - Reno Reno, Nevada  89502
South Jersey Healthcare Regional Cancer Center Millville, New Jersey  08332
Cancer Center at the Mountainside Hospital Montclair, New Jersey  07042
Atlantic City Medical Center - Mainland Division Pomona, New Jersey  08240
Capital Health System Regional Cancer Center Trenton, New Jersey  08618
Hematology-Oncology Associates, PC Albuquerque, New Mexico  87106
Lovelace Medical Center at Lovelace Sandia Health System Albuquerque, New Mexico  87108
Louis Busch Hager Cancer Center at Mary Imogene Bassett Hospital Cooperstown, New York  13326
Catskill Regional Medical Center Harris, New York  12742
Randolph Hospital Asheboro, North Carolina  27203
John Smith, Jr./Dalton McMichael Cancer Center at Morehead Memorial Hospital Eden, North Carolina  27288
Moses Cone Regional Cancer Center at Wesley Long Community Hospital Greensboro, North Carolina  27401
Annie Penn Cancer Center Reidsville, North Carolina  27320
Altru Cancer Center at Altru Hospital Grand Forks, North Dakota  58201
Akron City Hospital at Summa Health System Akron, Ohio  44304
University Hospitals Ireland Cancer Center at Mercy Medical Center Canton, Ohio  44708
Huron Hospital Cancer Care Center Cleveland, Ohio  44112
Euclid Hospital Cleveland, Ohio  44119
Miami Valley Hospital Dayton, Ohio  45409
Cancer Research UK Medical Oncology Unit at Churchill Hospital & Weatherall Institute of Molecular Medicine - Oxford Salem, Ohio  44460
Medical College of Ohio Cancer Institute Toledo, Ohio  43614
Toledo Clinic, Incorporated Toledo, Ohio  43623
South Pointe Hospital Cancer Care Center Warrensville Heights, Ohio  44122
Cancer Treatment Center Wooster, Ohio  44691
LaFortune Cancer Center at St. John Health System Tulsa, Oklahoma  74104
Comprehensive Cancer Center at Legacy Good Samaritan Hospital & Medical Center Portland, Oregon  97210
Institute of Oncology at Vilnius University Portland, Oregon  97227
Salem Hospital Regional Cancer Center Salem, Oregon  97309
John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital Allentown, Pennsylvania  18105
Cancer Center at Paoli Memorial Hospital Paoli, Pennsylvania  19301
Allegheny Cancer Center at Allegheny General Hospital Pittsburgh, Pennsylvania  15212
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital Pittsburgh, Pennsylvania  15224-1791
St. Joseph Medical Center Reading, Pennsylvania  19604
Guthrie Medical Center - Sayre Sayre, Pennsylvania  18840
Bon Secours Cancer Care at St. Mary's Hospital Richmond, Virginia  23226
Providence Cancer Institute at Providence Everett Medical Center - Pacific Campus Everett, Washington  98201
Cancer Care Center at Skagit Valley Hospital Mt. Vernon, Washington  98273
Cancer Center at Southwest Washington Medical Center Vancouver, Washington  98668
Midelfort Clinic - Luther Eau Claire, Wisconsin  54702
Luther Mildelfort Hospital Eau Claire, Wisconsin  54702
Central Wisconsin Cancer Program at Agnesian Health Care Fond Du Lac, Wisconsin  54935
St. Mary's Hospital Medical Center Green Bay, Wisconsin  54303
Vince Lombardi Cancer Clinic at St. Luke's Medical Center Milwaukee, Wisconsin  53215
All Saints Cancer Center at All Saints Healthcare Racine, Wisconsin  53405
West Allis Memorial Hospital West Allis, Wisconsin  53227