Tumor Replication Error (RER) Status and Outcome in a Colon Cancer Adjuvant Chemotherapy Trial
N/A
N/A
N/A
N/A
N/A
Not Enrolling
Both
Colorectal Cancer
Both
Colorectal Cancer
Trial Information
Tumor Replication Error (RER) Status and Outcome in a Colon Cancer Adjuvant Chemotherapy Trial
OBJECTIVES:
- Determine the relationship between disease free survival, overall survival, and tumor
replication error status for patients who have received adjuvant chemotherapy for colon
cancer on CALGB protocol 8896.
- Determine the prognostic and predictive values for response to this therapy in these
patients.
OUTLINE: Samples of tumor and normal tissue are obtained from CALGB 8896 patients. The
samples are tested for somatic mutations and tumor replication error (RER) tumor status.
Patients do not receive the results of the genetic testing and the results do not influence
the type or duration of treatment.
PROJECTED ACCRUAL: At least 300 specimens will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Patients who received chemotherapy for colon cancer as part of CALGB protocol 8896
- Underwent an initial resection for adenocarcinoma of the colon and were determined to
have a high risk of tumor recurrence based upon nodal disease or local extension of
tumor with obstruction or perforation due to tumor
- Surgical specimen blocks available, including tumor tissue and normal tissue
PATIENT CHARACTERISTICS:
Age:
- Not specified
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Not specified
Renal:
- Not specified
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- See Disease Characteristics
Endocrine therapy:
- Not specified
Radiotherapy:
- Not specified
Surgery:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Principal Investigator
Monica M. Bertagnolli, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Dana-Farber/Brigham and Women's Cancer Center
Authority:
United States: Federal Government
Study ID:
CDR0000066637
NCT ID:
NCT00003571
Start Date:
August 1998
Completion Date:
Related Keywords:
- Colorectal Cancer
- stage III colon cancer
- adenocarcinoma of the colon
- Colonic Neoplasms
- Colorectal Neoplasms
Name | Location |
|---|---|
| Roswell Park Cancer Institute | Buffalo, New York 14263 |
| Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
| Walter Reed Army Medical Center | Washington, District of Columbia 20307-5000 |
| University of Chicago Cancer Research Center | Chicago, Illinois 60637 |
| University of Massachusetts Memorial Medical Center | Worcester, Massachusetts 01655 |
| Lineberger Comprehensive Cancer Center, UNC | Chapel Hill, North Carolina 27599-7295 |
| Duke Comprehensive Cancer Center | Durham, North Carolina 27710 |
| Arthur G. James Cancer Hospital - Ohio State University | Columbus, Ohio 43210 |
| Rhode Island Hospital | Providence, Rhode Island 02903 |
| CCOP - Southern Nevada Cancer Research Foundation | Las Vegas, Nevada 89106 |
| University of California San Diego Cancer Center | La Jolla, California 92093-0658 |
| UCSF Cancer Center and Cancer Research Institute | San Francisco, California 94115-0128 |
| CCOP - Christiana Care Health Services | Wilmington, Delaware 19899 |
| CCOP - Mount Sinai Medical Center | Miami Beach, Florida 33140 |
| Marlene & Stewart Greenebaum Cancer Center, University of Maryland | Baltimore, Maryland 21201 |
| Ellis Fischel Cancer Center - Columbia | Columbia, Missouri 65203 |
| Barnes-Jewish Hospital | Saint Louis, Missouri 63110 |
| Norris Cotton Cancer Center | Lebanon, New Hampshire 03756 |
| CCOP - North Shore University Hospital | Manhasset, New York 11030 |
| State University of New York - Upstate Medical University | Syracuse, New York 13210 |
| CCOP - Southeast Cancer Control Consortium | Winston-Salem, North Carolina 27104-4241 |
| University of Tennessee, Memphis Cancer Center | Memphis, Tennessee 38103 |
| MBCCOP - Massey Cancer Center | Richmond, Virginia 23298-0037 |
| Mount Sinai Medical Center, NY | New York, New York 10029 |
| New York Presbyterian Hospital - Cornell Campus | New York, New York 10021 |
| Holden Comprehensive Cancer Center at The University of Iowa | Iowa City, Iowa 52242-1009 |
| Comprehensive Cancer Center at Wake Forest University | Winston-Salem, North Carolina 27157-1082 |
| Lombardi Cancer Center | Washington, District of Columbia 20007 |
| Veterans Affairs Medical Center - Birmingham | Birmingham, Alabama 35233 |
| Veterans Affairs Medical Center - White River Junction | White River Junction, Vermont 05009 |
| Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
| Veterans Affairs Medical Center - Chicago (Westside Hospital) | Chicago, Illinois 60612 |
| Veterans Affairs Medical Center - San Francisco | San Francisco, California 94121 |
| CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C. | Syracuse, New York 13217 |
| Veterans Affairs Medical Center - Memphis | Memphis, Tennessee 38104 |
| Veterans Affairs Medical Center - Richmond | Richmond, Virginia 23249 |
| Veterans Affairs Medical Center - Togus | Togus, Maine 04330 |
| Veterans Affairs Medical Center - Minneapolis | Minneapolis, Minnesota 55417 |
| Veterans Affairs Medical Center - Columbia (Truman Memorial) | Columbia, Missouri 65201 |
| University of Nebraska Medical Center | Omaha, Nebraska 68198-3330 |
| Veterans Affairs Medical Center - Buffalo | Buffalo, New York 14215 |
| Veterans Affairs Medical Center - Syracuse | Syracuse, New York 13210 |
| Veterans Affairs Medical Center - Durham | Durham, North Carolina 27705 |
| Schneider Children's Hospital at North Shore | Manhasset, New York 11030 |
