ECOG Laboratory Study: Mapping Interactive Cancer Susceptibility Loci
- Gather allele-sharing statistics at approximately 100 candidate loci throughout the
human genome most likely to influence genetic risk of cancer.
- Use these allele-sharing statistics to test the interaction of each locus individually
with cancer-associated, rare alleles of HRAS1.
- Generalize this approach for one of four cancers (breast, colon, lung, or prostate),
using allele-sharing statistics to test the interaction of each locus with every other
- Replicate positive results in a distinct set of sibling pairs with cancer.
- Examine, when loci contributing to risk are detected, the influence of this genetic
background on clinical outcomes, such as survival.
OUTLINE: Each patient-sibling pair completes a family history questionnaire about the
incidence of cancer in the family. Blood samples are obtained from both the patient and the
sibling (and both living parents, if available).
The blood samples are genotyped using approximately 300 micro-satellite markers flanking 100
candidate genes previously implicated in genetic risk for cancer. Certain loci are a
priority due to their association with HRAS1: BRCA1 and all known mismatch repair loci;
other repair genes, such as ATM; the Bloom's syndrome locus; and the XRCC group. Other genes
are also mapped.
Patients do not receive the results of the genetic testing and the results do not influence
the type and duration of treatment.
Patients only are followed annually.
PROJECTED ACCRUAL: This study will accrue 1,000 patient-sibling pairs for breast cancer.
After 18 months, another 1,000 patient-sibling pairs will be accrued for breast cancer.
Therefore, up to 2,000 patient-sibling pairs will be accrued over 5 years. (Feasibility of
accruing pairs for lung, colon, and prostate cancer is being assessed.)
United States: Federal Government
|Evanston Northwestern Healthcare - Evanston Hospital||Evanston, Illinois 60201-1781|
|Mercy Medical Center - Sioux City||Sioux City, Iowa 51104|
|Siouxland Hematology-Oncology Associates, LLP||Sioux City, Iowa 51101|
|St. Luke's Regional Medical Center||Sioux City, Iowa 51104|
|St. Vincent Hospital Regional Cancer Center||Green Bay, Wisconsin 54307-3508|
|Green Bay Oncology, Limited - Escanaba||Escanaba, Michigan 49431|
|Dickinson County Healthcare System||Iron Mountain, Michigan 49801|
|Our Lady of Mercy Medical Center Comprehensive Cancer Center||Bronx, New York 10466|
|St. Mary's Hospital Medical Center - Green Bay||Green Bay, Wisconsin 54303|
|Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center||Green Bay, Wisconsin 54301-3526|
|Green Bay Oncology, Limited at St. Mary's Hospital||Green Bay, Wisconsin 54303|
|Bay Area Cancer Care Center at Bay Area Medical Center||Marinette, Wisconsin 54143|
|Green Bay Oncology, Limited - Oconto Falls||Oconto Falls, Wisconsin 54154|
|Green Bay Oncology, Limited - Sturgeon Bay||Sturgeon Bay, Wisconsin 54235|
|CCOP - Nevada Cancer Research Foundation||Las Vegas, Nevada 89109-2306|
|Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School||New Brunswick, New Jersey 08903|
|Robert H. Lurie Comprehensive Cancer Center at Northwestern University||Chicago, Illinois 60611|
|Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton||Marlton, New Jersey 08053|
|Fox Chase Virtua Health Cancer Program at Virtua West Jersey||Voorhees, New Jersey 08043|
|Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center||Rancho Mirage, California 92270|
|Front Range Cancer Specialists||Fort Collins, Colorado 80528|
|Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital||Boca Raton, Florida 33486|
|Lakeland Regional Cancer Center at Lakeland Regional Medical Center||Lakeland, Florida 33805|
|Veterans Affairs Medical Center - Chicago Westside Hospital||Chicago, Illinois 60612|
|Hematology Oncology Associates - Skokie||Skokie, Illinois 60076|
|University Medical Center of Southern Nevada||Las Vegas, Nevada 89102|
|Finger Lakes Hematology and Oncology||Clifton Springs, New York 14432|
|Joan Karnell Cancer Center at Pennsylvania Hospital||Philadelphia, Pennsylvania 19107|
|UPMC Cancer Centers||Pittsburgh, Pennsylvania 15232|
|Jennersville Regional Hospital||West Grove, Pennsylvania 19390-9499|
|Fox Valley Hematology and Oncology - East Grant Street||Appleton, Wisconsin 54911-3496|
|All Saints Cancer Center at Wheaton Franciscan Healthcare||Racine, Wisconsin 53405|