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ECOG Laboratory Study: Mapping Interactive Cancer Susceptibility Loci

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Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer

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Trial Information

ECOG Laboratory Study: Mapping Interactive Cancer Susceptibility Loci


- Gather allele-sharing statistics at approximately 100 candidate loci throughout the
human genome most likely to influence genetic risk of cancer.

- Use these allele-sharing statistics to test the interaction of each locus individually
with cancer-associated, rare alleles of HRAS1.

- Generalize this approach for one of four cancers (breast, colon, lung, or prostate),
using allele-sharing statistics to test the interaction of each locus with every other

- Replicate positive results in a distinct set of sibling pairs with cancer.

- Examine, when loci contributing to risk are detected, the influence of this genetic
background on clinical outcomes, such as survival.

OUTLINE: Each patient-sibling pair completes a family history questionnaire about the
incidence of cancer in the family. Blood samples are obtained from both the patient and the
sibling (and both living parents, if available).

The blood samples are genotyped using approximately 300 micro-satellite markers flanking 100
candidate genes previously implicated in genetic risk for cancer. Certain loci are a
priority due to their association with HRAS1: BRCA1 and all known mismatch repair loci;
other repair genes, such as ATM; the Bloom's syndrome locus; and the XRCC group. Other genes
are also mapped.

Patients do not receive the results of the genetic testing and the results do not influence
the type and duration of treatment.

Patients only are followed annually.

PROJECTED ACCRUAL: This study will accrue 1,000 patient-sibling pairs for breast cancer.
After 18 months, another 1,000 patient-sibling pairs will be accrued for breast cancer.
Therefore, up to 2,000 patient-sibling pairs will be accrued over 5 years. (Feasibility of
accruing pairs for lung, colon, and prostate cancer is being assessed.)

Inclusion Criteria


- Histologically confirmed colon, lung, prostate, or invasive breast cancer

- No ductal or lobular carcinoma in situ of the breast only

- Patient and natural full sibling must have (or have had) cancer of the same type

- Participants in E-3Y92 not eligible

- Hormone receptor status:

- Not specified



- Not specified

Menopausal status:

- Not specified

Performance status:

- Not specified

Life expectancy:

- Not specified


- Not specified


- Not specified


- Not specified


Biologic therapy

- Not specified


- Not specified

Endocrine therapy

- Not specified


- Not specified


- Not specified

Type of Study:


Study Design:



United States: Federal Government

Study ID:




Start Date:

January 1998

Completion Date:

Related Keywords:

  • Breast Cancer
  • Colorectal Cancer
  • Lung Cancer
  • Prostate Cancer
  • stage I colon cancer
  • stage II colon cancer
  • stage III colon cancer
  • stage IV colon cancer
  • stage I breast cancer
  • stage II breast cancer
  • stage IIIA breast cancer
  • stage IIIB breast cancer
  • stage IIIC breast cancer
  • stage IV breast cancer
  • stage I non-small cell lung cancer
  • stage II non-small cell lung cancer
  • stage III non-small cell lung cancer
  • limited stage small cell lung cancer
  • extensive stage small cell lung cancer
  • stage I prostate cancer
  • stage II prostate cancer
  • stage III prostate cancer
  • stage IV prostate cancer
  • stage IV non-small cell lung cancer
  • Breast Neoplasms
  • Colorectal Neoplasms
  • Lung Neoplasms
  • Prostatic Neoplasms



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Mercy Medical Center - Sioux City Sioux City, Iowa  51104
Siouxland Hematology-Oncology Associates, LLP Sioux City, Iowa  51101
St. Luke's Regional Medical Center Sioux City, Iowa  51104
St. Vincent Hospital Regional Cancer Center Green Bay, Wisconsin  54307-3508
Green Bay Oncology, Limited - Escanaba Escanaba, Michigan  49431
Dickinson County Healthcare System Iron Mountain, Michigan  49801
Our Lady of Mercy Medical Center Comprehensive Cancer Center Bronx, New York  10466
St. Mary's Hospital Medical Center - Green Bay Green Bay, Wisconsin  54303
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center Green Bay, Wisconsin  54301-3526
Green Bay Oncology, Limited at St. Mary's Hospital Green Bay, Wisconsin  54303
Bay Area Cancer Care Center at Bay Area Medical Center Marinette, Wisconsin  54143
Green Bay Oncology, Limited - Oconto Falls Oconto Falls, Wisconsin  54154
Green Bay Oncology, Limited - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
CCOP - Nevada Cancer Research Foundation Las Vegas, Nevada  89109-2306
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School New Brunswick, New Jersey  08903
Robert H. Lurie Comprehensive Cancer Center at Northwestern University Chicago, Illinois  60611
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton Marlton, New Jersey  08053
Fox Chase Virtua Health Cancer Program at Virtua West Jersey Voorhees, New Jersey  08043
Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center Rancho Mirage, California  92270
Front Range Cancer Specialists Fort Collins, Colorado  80528
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital Boca Raton, Florida  33486
Lakeland Regional Cancer Center at Lakeland Regional Medical Center Lakeland, Florida  33805
Veterans Affairs Medical Center - Chicago Westside Hospital Chicago, Illinois  60612
Hematology Oncology Associates - Skokie Skokie, Illinois  60076
University Medical Center of Southern Nevada Las Vegas, Nevada  89102
Finger Lakes Hematology and Oncology Clifton Springs, New York  14432
Joan Karnell Cancer Center at Pennsylvania Hospital Philadelphia, Pennsylvania  19107
UPMC Cancer Centers Pittsburgh, Pennsylvania  15232
Jennersville Regional Hospital West Grove, Pennsylvania  19390-9499
Fox Valley Hematology and Oncology - East Grant Street Appleton, Wisconsin  54911-3496
All Saints Cancer Center at Wheaton Franciscan Healthcare Racine, Wisconsin  53405