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ECOG Laboratory Study: Mapping Interactive Cancer Susceptibility Loci

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Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer

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Trial Information

ECOG Laboratory Study: Mapping Interactive Cancer Susceptibility Loci


- Gather allele-sharing statistics at approximately 100 candidate loci throughout the
human genome most likely to influence genetic risk of cancer.

- Use these allele-sharing statistics to test the interaction of each locus individually
with cancer-associated, rare alleles of HRAS1.

- Generalize this approach for one of four cancers (breast, colon, lung, or prostate),
using allele-sharing statistics to test the interaction of each locus with every other

- Replicate positive results in a distinct set of sibling pairs with cancer.

- Examine, when loci contributing to risk are detected, the influence of this genetic
background on clinical outcomes, such as survival.

OUTLINE: Each patient-sibling pair completes a family history questionnaire about the
incidence of cancer in the family. Blood samples are obtained from both the patient and the
sibling (and both living parents, if available).

The blood samples are genotyped using approximately 300 micro-satellite markers flanking 100
candidate genes previously implicated in genetic risk for cancer. Certain loci are a
priority due to their association with HRAS1: BRCA1 and all known mismatch repair loci;
other repair genes, such as ATM; the Bloom's syndrome locus; and the XRCC group. Other genes
are also mapped.

Patients do not receive the results of the genetic testing and the results do not influence
the type and duration of treatment.

Patients only are followed annually.

PROJECTED ACCRUAL: This study will accrue 1,000 patient-sibling pairs for breast cancer.
After 18 months, another 1,000 patient-sibling pairs will be accrued for breast cancer.
Therefore, up to 2,000 patient-sibling pairs will be accrued over 5 years. (Feasibility of
accruing pairs for lung, colon, and prostate cancer is being assessed.)

Inclusion Criteria


- Histologically confirmed colon, lung, prostate, or invasive breast cancer

- No ductal or lobular carcinoma in situ of the breast only

- Patient and natural full sibling must have (or have had) cancer of the same type

- Participants in E-3Y92 not eligible

- Hormone receptor status:

- Not specified



- Not specified

Menopausal status:

- Not specified

Performance status:

- Not specified

Life expectancy:

- Not specified


- Not specified


- Not specified


- Not specified


Biologic therapy

- Not specified


- Not specified

Endocrine therapy

- Not specified


- Not specified


- Not specified

Type of Study:


Study Design:



United States: Federal Government

Study ID:




Start Date:

January 1998

Completion Date:

Related Keywords:

  • Breast Cancer
  • Colorectal Cancer
  • Lung Cancer
  • Prostate Cancer
  • stage I colon cancer
  • stage II colon cancer
  • stage III colon cancer
  • stage IV colon cancer
  • stage I breast cancer
  • stage II breast cancer
  • stage IIIA breast cancer
  • stage IIIB breast cancer
  • stage IIIC breast cancer
  • stage IV breast cancer
  • stage I non-small cell lung cancer
  • stage II non-small cell lung cancer
  • stage III non-small cell lung cancer
  • limited stage small cell lung cancer
  • extensive stage small cell lung cancer
  • stage I prostate cancer
  • stage II prostate cancer
  • stage III prostate cancer
  • stage IV prostate cancer
  • stage IV non-small cell lung cancer
  • Breast Neoplasms
  • Colorectal Neoplasms
  • Lung Neoplasms
  • Prostatic Neoplasms



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