Know Cancer

or
forgot password

ECOG Laboratory Study: Mapping Interactive Cancer Susceptibility Loci


N/A
N/A
N/A
Not Enrolling
Both
Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer

Thank you

Trial Information

ECOG Laboratory Study: Mapping Interactive Cancer Susceptibility Loci


OBJECTIVES:

- Gather allele-sharing statistics at approximately 100 candidate loci throughout the
human genome most likely to influence genetic risk of cancer.

- Use these allele-sharing statistics to test the interaction of each locus individually
with cancer-associated, rare alleles of HRAS1.

- Generalize this approach for one of four cancers (breast, colon, lung, or prostate),
using allele-sharing statistics to test the interaction of each locus with every other
locus.

- Replicate positive results in a distinct set of sibling pairs with cancer.

- Examine, when loci contributing to risk are detected, the influence of this genetic
background on clinical outcomes, such as survival.

OUTLINE: Each patient-sibling pair completes a family history questionnaire about the
incidence of cancer in the family. Blood samples are obtained from both the patient and the
sibling (and both living parents, if available).

The blood samples are genotyped using approximately 300 micro-satellite markers flanking 100
candidate genes previously implicated in genetic risk for cancer. Certain loci are a
priority due to their association with HRAS1: BRCA1 and all known mismatch repair loci;
other repair genes, such as ATM; the Bloom's syndrome locus; and the XRCC group. Other genes
are also mapped.

Patients do not receive the results of the genetic testing and the results do not influence
the type and duration of treatment.

Patients only are followed annually.

PROJECTED ACCRUAL: This study will accrue 1,000 patient-sibling pairs for breast cancer.
After 18 months, another 1,000 patient-sibling pairs will be accrued for breast cancer.
Therefore, up to 2,000 patient-sibling pairs will be accrued over 5 years. (Feasibility of
accruing pairs for lung, colon, and prostate cancer is being assessed.)

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Histologically confirmed colon, lung, prostate, or invasive breast cancer

- No ductal or lobular carcinoma in situ of the breast only

- Patient and natural full sibling must have (or have had) cancer of the same type

- Participants in E-3Y92 not eligible

- Hormone receptor status:

- Not specified

PATIENT CHARACTERISTICS:

Age:

- Not specified

Menopausal status:

- Not specified

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- Not specified

Endocrine therapy

- Not specified

Radiotherapy

- Not specified

Surgery

- Not specified

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

CDR0000066283

NCT ID:

NCT00003329

Start Date:

January 1998

Completion Date:

Related Keywords:

  • Breast Cancer
  • Colorectal Cancer
  • Lung Cancer
  • Prostate Cancer
  • stage I colon cancer
  • stage II colon cancer
  • stage III colon cancer
  • stage IV colon cancer
  • stage I breast cancer
  • stage II breast cancer
  • stage IIIA breast cancer
  • stage IIIB breast cancer
  • stage IIIC breast cancer
  • stage IV breast cancer
  • stage I non-small cell lung cancer
  • stage II non-small cell lung cancer
  • stage III non-small cell lung cancer
  • limited stage small cell lung cancer
  • extensive stage small cell lung cancer
  • stage I prostate cancer
  • stage II prostate cancer
  • stage III prostate cancer
  • stage IV prostate cancer
  • stage IV non-small cell lung cancer
  • Breast Neoplasms
  • Colorectal Neoplasms
  • Lung Neoplasms
  • Prostatic Neoplasms

Name

Location

Evanston Northwestern Healthcare - Evanston HospitalEvanston, Illinois  60201-1781
Mercy Medical Center - Sioux CitySioux City, Iowa  51104
Siouxland Hematology-Oncology Associates, LLPSioux City, Iowa  51101
St. Luke's Regional Medical CenterSioux City, Iowa  51104
St. Vincent Hospital Regional Cancer CenterGreen Bay, Wisconsin  54307-3508
Green Bay Oncology, Limited - EscanabaEscanaba, Michigan  49431
Dickinson County Healthcare SystemIron Mountain, Michigan  49801
Our Lady of Mercy Medical Center Comprehensive Cancer CenterBronx, New York  10466
St. Mary's Hospital Medical Center - Green BayGreen Bay, Wisconsin  54303
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer CenterGreen Bay, Wisconsin  54301-3526
Green Bay Oncology, Limited at St. Mary's HospitalGreen Bay, Wisconsin  54303
Bay Area Cancer Care Center at Bay Area Medical CenterMarinette, Wisconsin  54143
Green Bay Oncology, Limited - Oconto FallsOconto Falls, Wisconsin  54154
Green Bay Oncology, Limited - Sturgeon BaySturgeon Bay, Wisconsin  54235
CCOP - Nevada Cancer Research FoundationLas Vegas, Nevada  89109-2306
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical SchoolNew Brunswick, New Jersey  08903
Robert H. Lurie Comprehensive Cancer Center at Northwestern UniversityChicago, Illinois  60611
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital MarltonMarlton, New Jersey  08053
Fox Chase Virtua Health Cancer Program at Virtua West JerseyVoorhees, New Jersey  08043
Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical CenterRancho Mirage, California  92270
Front Range Cancer SpecialistsFort Collins, Colorado  80528
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community HospitalBoca Raton, Florida  33486
Lakeland Regional Cancer Center at Lakeland Regional Medical CenterLakeland, Florida  33805
Veterans Affairs Medical Center - Chicago Westside HospitalChicago, Illinois  60612
Hematology Oncology Associates - SkokieSkokie, Illinois  60076
University Medical Center of Southern NevadaLas Vegas, Nevada  89102
Finger Lakes Hematology and OncologyClifton Springs, New York  14432
Joan Karnell Cancer Center at Pennsylvania HospitalPhiladelphia, Pennsylvania  19107
UPMC Cancer CentersPittsburgh, Pennsylvania  15232
Jennersville Regional HospitalWest Grove, Pennsylvania  19390-9499
Fox Valley Hematology and Oncology - East Grant StreetAppleton, Wisconsin  54911-3496
All Saints Cancer Center at Wheaton Franciscan HealthcareRacine, Wisconsin  53405