A Phase II Trial of Preradiation Multiagent Chemotherapy for Adults With "Poor Risk" Medulloblastoma, PNET, and Disseminated Ependymoma
- Determine the complete and partial response rate of patients with adult
medulloblastoma, primitive neuroectodermal tumor, or disseminated ependymoma treated
with preradiation combination chemotherapy.
- Determine the progression free survival and overall survival of these adult patients
treated with combination chemotherapy followed by craniospinal radiation.
- Determine the toxic effects associated with this treatment in these patients.
OUTLINE: Patients receive cisplatin IV over 6 hours, etoposide IV, and vincristine IV over
1-2 minutes on day 1; etoposide IV and cyclophosphamide IV over 1-2 hours on days 2-3;
filgrastim (G-CSF) subcutaneously (SC) on days 4-13; and vincristine IV over 1-2 minutes on
day 15. Treatment repeats every 42 days for up to 3 courses in the absence of disease
progression or unacceptable toxicity.
Within 4-6 weeks after the last chemotherapy course, patients undergo radiotherapy 5 days a
week for 6 to 7 weeks.
Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then
annually for 5-10 years.
PROJECTED ACCRUAL: A total of 33 patients will be accrued for this study within 3 years.
Primary Purpose: Treatment
Paul L. Moots, MD
Vanderbilt-Ingram Cancer Center
United States: Food and Drug Administration
|H. Lee Moffitt Cancer Center and Research Institute||Tampa, Florida 33612|
|CCOP - Wichita||Wichita, Kansas 67214-3882|
|CCOP - Carle Cancer Center||Urbana, Illinois 61801|
|CCOP - Iowa Oncology Research Association||Des Moines, Iowa 50309-1016|
|CCOP - Kalamazoo||Kalamazoo, Michigan 49007-3731|
|CCOP - Metro-Minnesota||Saint Louis Park, Minnesota 55416|
|West Michigan Cancer Center||Kalamazoo, Michigan 49007-3731|
|Medical College of Wisconsin Cancer Center||Milwaukee, Wisconsin 53226|
|CCOP - Cedar Rapids Oncology Project||Cedar Rapids, Iowa 52403-1206|
|Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center||Lebanon, New Hampshire 03756-0002|
|Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center||Nashville, Tennessee 37232-2516|
|Veterans Affairs Medical Center - Lakeside Chicago||Chicago, Illinois 60611|
|CCOP - Marshfield Clinic Research Foundation||Marshfield, Wisconsin 54449|
|Robert H. Lurie Comprehensive Cancer Center at Northwestern University||Chicago, Illinois 60611|