Inclusion Criteria:

- Patients must have Stage III-IV (Ann Arbor classification) low-grade Non-Hodgkin's
lymphoma

- Baseline measurements and evaluations must be obtained within 4 weeks prior to
registration; all areas of disease (evaluable and measurable) should be recorded and
mapped out in order to assess response and uniformity of response to therapy; must
have at least one objective MEASURABLE disease parameter

- Radiographic findings are acceptable providing that clear-cut measurement can be
made

- Abnormalities on scans may be used to document the presence of disease for
staging purposes; a clearly defined, bidimensionally measurable defect or mass
measuring at least 2 cm in diameter on a radionuclide or a CT scan will be
acceptable as measurable disease

- An enlarged spleen extending at least 2 cm below the costal margin will
constitute measurable disease providing that no explanation other than
lymphomatous involvement is likely; for an enlarged liver to constitute the only
evident measurable disease parameter, liver biopsy proof of lymphoma in the
liver is required

- Patients must have a tissue diagnosis of low-grade malignant lymphoma obtained within
12 months prior to registration (according to the International Working Formulation)
as below:

- ML- small lymphocytic (Category A)

- ML-follicular-small cleaved (Category B)

- ML-follicular-mixed small cleaved and large cell (Category C)

- Patients having both diffuse and follicular architectural elements will be considered
eligible if the histology is predominantly follicular (i.e. >= 50% of the
cross-sectional area); if the interval since tissue diagnosis of low-grade malignant
lymphoma is > 12 months, diagnostic confirmation using either FNA or nodal biopsy is
required to confirm that the histology remains in one of the eligible categories

- Women of child bearing potential and sexually active males are strongly advised to
use an accepted and effective method of birth control

- No prior chemotherapy, radiotherapy, or immunotherapy

- No active, uncontrolled infections (afebrile for > 48 hours off antibiotics)

- No evidence of a previous or concurrent malignancy, with the exception of 1) treated
carcinoma in situ of the cervix, 2) treated squamous cell or basal cell skin cancer
OR 3) any other surgically cured malignancy from which the patient has been disease
free for at least 5 years

- ECOG performance status 0-1

- WBC > 3000/mm^3

- Plts > 100,000/mm^3

- Creatinine =< 1.5 mg/dl

- Bilirubin < 2.0 mg/dl

- LFTs =< 5x ULN (SGOT and Alkaline Phosphate)

- These lab values must be obtained within 4 weeks prior to protocol entry; patients
with documented marrow involvement at the time of registration are not required to
meet the hematologic parameters above

- Patient must give signed informed consent