A RANDOMISED TRIAL OF INTRAVENOUS VERSUS INTRAHEPATIC ARTERIAL 5-FU AND LEUCOVORIN FOR COLORECTAL LIVER METASTASES
OBJECTIVES: I. Compare the survival and response rates of patients with colorectal liver
metastases treated with intravenous vs. intrahepatic arterial infusion of
fluorouracil/leucovorin. II. Assess the effect of these 2 treatments on symptoms and quality
of life of these patients.
OUTLINE: Randomized study. Patients randomized to Arm II should have a preoperative hepatic
angiography; at laparotomy, an intrahepatic arterial catheter is fused into the
gastroduodenal artery to establish an infusion of both lobes of the liver. Arm I:
Single-Agent Chemotherapy with Drug Modulation. Fluorouracil, 5-FU, NSC-19893; with
Leucovorin calcium, CF, NSC-3590. Intravenous infusion. Arm II: Single-Agent Chemotherapy
with Drug Modulation. 5-FU; with CF. Intrahepatic arterial infusion.
PROJECTED ACCRUAL: 312 patients are expected to be randomized within 3-4 years.
Allocation: Randomized, Primary Purpose: Treatment
David J. Kerr, MD, FRCP, DSc
University Hospital Birmingham
United States: Federal Government