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Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection


N/A
N/A
N/A
Not Enrolling
Both
Blastomycosis

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Trial Information

Evaluation of the Association of Polymorphisms in the Innate Immune System With the Risk for Blastomycosis Dermatitidis Infection in Patients Not Infected With HIV and Complications Associated With Blastomycosis Dermatitidis Infection


Innate immunity plays an important role for fungal recognition and initiation of fungicidal
activity. We hypothesize that subtle differences in different molecules of innate immunity
may contribute to either the predisposition or clinical course of infection with
Blastomycosis Dermatitidis. To test this hypothesis, we propose to analyze the allelic
frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor Ila and IIb,
Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta,
interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1,
chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to
compare this data to the incidence and severity of Blastomycosis Dermatitidis infection.
With this study we hope to identify a group of molecules of innate immunity which influence
the risk and severity of invasive Blastomycosis Dermatitidis infection.

Inclusion Criteria


- INCLUSION CRITERIA:

Patients in the database have been confirmed with a diagnosis of Blastomycosis
dermatitides infection by a combination of isolation of the yeast form in a diagnostic
microbiology laboratory and/or an elevated cryptococcal antigen titer (which is
commercially available).

Only patients diagnosed and treated in the United States and Canada will be included in
this analysis.

Only patients who are not co-infected with HIV will be included in the study.

Patient samples will be collected and clinical data will be evaluated only after signed
consent has been obtained.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

980138

NCT ID:

NCT00001702

Start Date:

July 1998

Completion Date:

Related Keywords:

  • Blastomycosis
  • Genetic
  • Variant Alleles
  • Risk Factor
  • Cancer
  • Transplantation
  • Blastomycosis

Name

Location

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland  20892
University of AlabamaBirmingham, Alabama