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Culture and Characteristics of Mastocytosis Mast Cells


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Mastocytosis

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Trial Information

Culture and Characteristics of Mastocytosis Mast Cells


This protocol is designed to examine those growth potentiating and inhibiting factors which
regulate mast cell number in patients with mastocytosis, and to explore the molecular basis
of the disease process in hopes of improving therapy. Patients entered into the study are
seen initially and may elect to be reevaluated yearly. The majority of patients to be
entered into this protocol are currently followed at NIH on other protocols. Medical workup
and treatment are in accordance with standard medical practice. The protocol is for 3
years, to be extended as facilities, faculty, and patients permit.

Inclusion Criteria


Subjects include children and adults from birth to 80 years of age.

Participants must have histologic evidence of an increased mast cell number in at least
one organ system.

Must be willing to be seen at the NIH according to protocol guidelines.

Routine medical care must be available through their referral physician.

Patients with mastocytosis now followed at the NIH on protocol 88-I-0190 will be continued
on this study.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

930136

NCT ID:

NCT00001356

Start Date:

May 1993

Completion Date:

May 2002

Related Keywords:

  • Mastocytosis
  • IL-3
  • Stem Cell Factor
  • Cytokines
  • Cell Differentiation
  • Receptors
  • Bone Marrow
  • Mastocytosis
  • Mastocytosis
  • Urticaria Pigmentosa
  • Mastocytoma

Name

Location

National Institute of Allergy and Infectious Diseases (NIAID)Bethesda, Maryland  20892