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Medical Therapy of Zollinger-Ellison Syndrome


N/A
18 Years
N/A
Not Enrolling
Both
Zollinger Ellison Syndrome

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Trial Information

Medical Therapy of Zollinger-Ellison Syndrome


This protocol describes the use of histamine H2-receptor antagonists to control gastric acid
hypersecretion in patients with Zollinger-Ellison syndrome. It details which patients will
be considered for treatment with these agents, the pretreatment procedures and the
procedures to be followed in establishing the proper intravenous dose of histamine
H2-receptor antagonist. It also details the procedure to be used to establish a safe and
effective oral long-term maintenance dose of either cimetidine, ranitidine, nizatidine, or
famotidine. By following these procedures it will be possible to evaluate the effectiveness
of intravenous histamine H2 therapy if it is determined this is important for antisecretory
control during periods when patients cannot take oral gastric antisecretory agents. It will
also be possible to evaluate the effectiveness of histamine H2-receptor in patients with
Zollinger-Ellison syndrome after successful gastrinoma resection who continue to have mild
gastric hypersecretion.

Inclusion Criteria


- INCLUSION CRITERIA:

Basal gastric acid secretion of greater than 15 mEq/hr (normal less than 10) or greater
than 5 mEq/hr if they have had a previous gastric resection, a fasting plasma
concentration of immunoreactive gastrin of greater than 100 pg/ml (normal less than 100),
a positive secretin provocative tests or histological diagnosis of gastrinoma.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

890015

NCT ID:

NCT00001241

Start Date:

January 1989

Completion Date:

December 2007

Related Keywords:

  • Zollinger Ellison Syndrome
  • Gastric Acid Secretion
  • Histamine H2-Receptor Antagonists
  • Zollinger-Ellison Syndrome
  • Gastrinoma

Name

Location

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland  20892