Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed* malignancy at original diagnosis or relapse, including the
following:

- Solid tumors (phase I)

- CNS tumors (phase I)

- Neurologic deficits must have been relatively stable for ≥ 1 week before
study enrollment

- Anaplastic large cell lymphoma (ALCL) (phase I or II)

- No primary cutaneous ALCL

- Confirmed anaplastic lymphoma kinase (ALK) fusion proteins, ALK mutations, or
ALK amplification (defined as > 4-fold increase in the ALK signal number as
compared to reference signal number on chromosome 2q arm) (phase I)

- Neuroblastoma (phase I or II) NOTE: *Histologic confirmation is not required for
patients with diffuse intrinsic brain stem tumors, optic pathway tumors, or
pineal region tumors with elevations of serum or CSF tumor markers (e.g.,
alpha-fetoprotein or beta-HCG).

- Relapsed or refractory disease

- Measurable and/or evaluable disease

- Patients with neuroblastoma must have measurable tumor on MRI, CT scan, or x-ray
obtained within the past 2 weeks and/or evaluable tumor by MIBG scan and/or bone
marrow involvement with tumor cells seen on routine morphology

- Patients with ALCL enrolled in the phase II portion of the trial must have
measurable disease

- No known curative therapy or therapy proven to prolong survival with an acceptable
quality of life exists

PATIENT CHARACTERISTICS:

- Karnofsky performance status (PS) 50-100% (for patients > 16 years of age) or Lansky
PS 50-100% (for patients ≤ 16 years of age)

- Patients who are up in a wheelchair and are unable to walk due to paralysis will
be considered ambulatory for the purpose of assessing PS

- ANC ≥ 1,000/mm^3 (≥ 750/mm^3 in patients with metastatic bone marrow disease)

- Platelet count ≥ 75,000/mm^3 (transfusion independent, defined as no platelet
transfusions within the past 7 days) in patients without bone marrow involvement OR ≥
25,000/mm^3 (platelet transfusions allowed) in patients with metastatic bone marrow
disease

- Hemoglobin ≥ 8.0 g/dL (RBC transfusions allowed)

- Creatinine clearance or radioisotope GFR ≥ 70 mL/min OR serum creatinine based on
age/gender as follows:

- ≤ 0.6 mg/dL (for patients 1 year of age)

- ≤ 0.8 mg/dL (for patients 2 to 5 years of age)

- ≤ 1.0 mg/dL (for patients 6 to 9 years of age)

- ≤ 1.2 mg/dL (for patients 10 to 12 years of age)

- ≤ 1.4 mg/dL (for female patients ≥ 13 years of age)

- ≤ 1.5 mg/dL (for male patients 13 to 15 years of age)

- ≤ 1.7 mg/dL (for male patients ≥ 16 years of age)

- Bilirubin (sum of conjugated and unconjugated) ≤ 1.5 times upper limit of normal for
age

- SGPT ≤ 110 U/L

- Serum albumin ≥ 2 g/dL

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- Body surface area ≥ 0.4 mm² (for patients enrolled at dose levels 0 and 1 only)

- Able to swallow capsules or a liquid suspension/solution

- Able to comply with the safety monitoring requirements of the study, in the opinion
of the investigator

- No uncontrolled infection

- No evidence of active graft vs host disease

- Not refractory to red cell or platelet transfusion (in patients with metastatic bone
marrow disease)

PRIOR CONCURRENT THERAPY:

- Recovered from prior chemotherapy, immunotherapy, or radiotherapy

- No prior crizotinib

- At least 6 months since prior total-body radiotherapy (TBI), craniospinal
radiotherapy, or radiotherapy to ≥ 50% of the pelvis

- At least 3 months since prior bone marrow or stem cell transplant (without TBI) (≥ 6
weeks for patients with neuroblastoma or patients with confirmed ALK fusion proteins,
ALK mutations, or ALK amplification)

- No evidence of active graft-vs-host disease

- At least 6 weeks since prior therapeutic doses of MIBG

- At least 6 weeks since other prior substantial bone marrow radiotherapy

- At least 2 weeks since prior local palliative radiotherapy (small port)

- More than 3 weeks since prior myelosuppressive chemotherapy (6 weeks for
nitrosoureas) for patients with solid tumors

- At least 14 days since prior cytotoxic therapy for patients with ALCL who relapse
while receiving cytotoxic therapy

- Patients with lymphoma who relapse during standard maintenance therapy are
eligible at time of relapse

- Cytoreduction with hydroxyurea may be initiated and continued for up to 24 hours
before the start of study treatment

- At least 7 days since prior growth factor therapy

- At least 7 days since prior biological agents

- At least 7 days or 3 half-lives (whichever is longer) since prior monoclonal antibody

- More than 12 days since prior and no concurrent potent CYP3A4 inducers including, but
not limited to carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin,
tipranavir, ritonavir, or St. John wort

- More than 7 days since prior and no concurrent potent CYP3A4 inhibitors including,
but not limited to ketoconazole, itraconazole, miconazole, clarithromycin,
erythromycin, ritonavir, indinavir, nelfinavir, saquinavir, amprenavir, delavirdine,
nefazodone, diltiazem, verapamil, or grapefruit juice

- No concurrent medications known to be metabolized by CYP3A4 with narrow therapeutic
indices, including pimozide, aripiprazole, triazolam, ergotamine, and halofantrine

- No other concurrent anticancer therapy (including chemotherapy, radiotherapy,
immunotherapy, or biologic therapy), except for hydroxyurea for patients with ALCL or
decadron for patients with CNS tumors

- No other concurrent investigational drugs

- Concurrent corticosteroids for CNS tumors allowed provided the dose has been stable
or decreasing for the past 7 days