Early Detection of Lung Cancer in a High-Risk Population Defined by Pulmonary Function Testing, Biomarkers, and Computerized Tomography Scanning

Inclusion Criteria:

- Age 55-75 years old.

- Identification of a primary care physician (can be identified by study staff if
needed).

- FEV1/FVC <70% (GOLD 1 or higher COPD) (poor breathing function).

- > or = 40 pack-year current or former (within the last 10 years) tobacco use (i.e.
heavy cigarette smoking history).

Exclusion Criteria:

- Enrolled in any other lung screening or lung cancer prevention trial.

- Chest CT within the prior 12 months.

- Inability to lie flat with arms raised above the head.

- Current or prior personal history of lung cancer.

- Prior history of cancer within the last five years or currently receiving treatment
for cancer, except adequately treated non-melanomatous skin cancer or in-situ
cervical cancer.

- Life expectancy of less than 5 years.

- Patients requiring supplemental oxygen.

- Inability to give informed consent.