Physiological Mechanisms Underlying the Effects of PUFA and Antioxidants on Postprandial Lipemia, Oxidative Stress, Endothelial Dysfunction and Inflammation in Men

Inclusion Criteria:

- Waist circumference > 90 cm

- Fasting triglycerides > 1.7 mmol/L

- No use (ever) of medications for the treatment for dyslipidemia or hypertension

Exclusion Criteria:

- Alcohol consumption > 1 drink per day i.e ~15 g of alcohol/day or the equivalent of 1
beer (12 oz or 341 mL), 1 glass of wine (4 oz or 125 mL) or 1 ounce (30 mL) of
liquor.

- Chronic use of supplements (vitamins, minerals or flavonoids)

- Body mass index > 35 kg/m2

- Chronic diseases: CHD, diabetes, etc.

- Smokers (1 or more cigarette/day)

- Dyslipidemia secondary to renal insufficiency, hypothyroidism or others

- Any prior or current use of medications known to affect lipoprotein-lipid metabolism
(e.g. statins, fibrates), endothelial function (hypotensive drugs). Use (ever) of
anticoagulant drugs (e.g. warfarin) because of possible detrimental interaction with
the consumption of cranberry juice. Current or recent (<2 weeks) use of
anti-inflammatory drugs Note: If for any reason, a subject would have to go an any of
these drugs during the protocol, they would be automatically dropped from the study.