Inclusion Criteria:

- 18 years or older

- Suspicious diagnosis of or histologically- confirmed stage IIIB or IV non small-cell
lung cancer

- Accessible and adequate tumor source for vaccine production.

- Tumor source for vaccine production must be accessible by a minor surgical procedure
performed under local or regional anesthesia (e.g. lymph node or soft tissue mass or
malignant pleural effusion)

- Measurable disease to evaluate following tumor procurement

- Limited metastatic tumor burden

- Life expectancy at least 4 months

- ECOG Performance Status 0 - 1

Exclusion Criteria:

- Active and/or untreated brain metastases

- Active or impending spinal cord compression

- Active auto-immune disease or treatment with immunosuppressants

- Decompensated congestive heart failure or recent significant cardiac event

- Coexisting malignancies

- Significant or uncontrolled medical problems or laboratory abnormalities that might
increase the risk of surgical complications or vaccine treatment

- Previous treatment with gene therapy (including any adenoviral-based therapy)