Trial Information

Treatment Decision Intervention for Veterans With Prostate Cancer

Background:

Newly diagnosed localized prostate cancer patients face difficult decisions about treatment
and management; including radiation therapy, radical prostatectomy, brachytherapy, and
observation. Previous studies have cited patient preference and physician recommendation
for treatment as major roles in treatment decisions.

Objectives:

This grant will be used to develop and evaluate a decision analysis based intervention to
improve decision-making among veterans with newly diagnosed localized prostate cancer.
While the ultimate goal of this study is to improve decision-making among these patients,
factors influencing physician recommendations for treatment will be sought. The former will
be achieved by evaluating the efficacy of providing physicians with information
incorporating patient preference for alternative health states with probabilities of
treatment outcomes. Factors influencing physician recommendations for treatment will be
determined through qualitative interviews with physicians.

Methods:

Patients were accrued at the VA Chicago Health Care System Lakeside Urology Clinic. Upon
consent for participation in the study, comorbidities, histologic grade of the biopsy, and
age were obtained for 13 patients with newly diagnosed localized prostate cancer. Using a
standard gamble technique, interviewers obtained patient utilities for 5 distinct health
states related to prostate cancer treatment. Clinical and pathologic characteristics were
incorporated into the decision analytic model, and the derived quality-adjusted life
expectancies (QALEs) were shared with the treating urologist before patient-physician
discussion of treatment options. The feasibility of the decision analytic intervention and
unbiased estimates of the impact of the intervention was evaluated. The long-range
objective of this proposal is to design an intervention for veterans that increases
physician understanding of patient treatment preferences and patient understanding of
choices in prostate cancer treatment.

Status:

Completed