Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically or cytologically confirmed Mullerian carcinoma
(ovarian epithelial or peritoneal carcinoma) (closed to accrual as of 8/23/01) OR
Gastrointestinal cancer with abdominal carcinomatosis OR Peritoneal mesothelioma (closed
to accrual as of 8/23/01) Must have received an adequate course of any platinum-based
chemotherapy regimen for ovarian cancer with evidence of intraabdominal disease Must have
received an adequate course of fluorouracil-based treatment for metastatic colon cancer
Intact primary gastrointestinal tumor allowed if not at risk of obstruction and/or
bleeding Abdominal lesions must be less than 10 cm Extraperitoneal lesions must be less
than 2 cm No hepatic disease No clinically significant pleural effusion (controlled by
pleurodesis allowed) No brain metastases No significant adhesions or symptoms of
obstruction

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Zubrod 0-2 Life expectancy:
Not specified Hematopoietic: Absolute granulocyte count at least 1,500/mm3 Platelet count
at least 100,000/mm3 Hemoglobin at least 9 g/dL (transfusion allowed) Lymphocyte count at
least 800/mm3 Hepatic: See Disease Characteristics Bilirubin no greater than 1.5 mg/dL
SGOT or SGPT less than 2.5 times upper limit of normal Albumin at least 3.5 g/dL Hepatitis
B and C negative Renal: Creatinine no greater than 1.5 mg/dL Cardiovascular: No
significant heart disease Other: Not pregnant or nursing Negative pregnancy test Fertile
patients must use effective contraception Loss of no more than 10% of body weight over a 4
month period No overt autoimmune disease No active ulcer disease No prior inflammatory
bowel disease (e.g., Crohn's disease or ulcerative colitis)

PRIOR CONCURRENT THERAPY: Biologic therapy: No other concurrent immunotherapy
Chemotherapy: At least 3 weeks since prior chemotherapy (6 weeks for mitomycin or
nitrosoureas) and recovered No concurrent chemotherapy Endocrine therapy: No chronic
steroid therapy Radiotherapy: At least 3 months since prior localized radiotherapy (e.g.,
pelvic or small field) and recovered No radiotherapy to whole abdomen No concurrent
radiotherapy Surgery: Recovered from prior surgery At least 3 weeks since prior major
abdominal surgery At least 2 weeks since prior laparoscopy