Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed extragonadal and gonadal germ cell tumor
Seminoma and nonseminoma eligible Recurrent or refractory disease despite adequate
first-line cisplatin- or carboplatin-based chemotherapy and not amenable to surgery and/or
curative radiotherapy Relapse after disease-free interval of 1 or more years ineligible
Measurable or evaluable disease with documented progression within 2 months prior to entry
Elevated beta human chorionic gonadotropin and alpha-fetoprotein considered evaluable if
no other evaluable lesion and provided marker(s): Increased since end of last treatment At
least 10 times upper limit of normal unless due to tumor lysis Rising on 3 successive
occasions at least 2-3 days apart If no tumor markers available, cytology or histology
should be obtained No inadequately treated CNS metastases No pleural or pericardial
effusion and/or ascites

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: WHO 0-2 Life expectancy: At
least 3 months Hematopoietic: Absolute granulocyte count at least 2,000/mm3 Platelet count
at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.25 times normal AST/ALT no
greater than 3 times normal Alkaline phosphatase no greater than 2.5 times normal Renal:
Creatinine no greater than 1.6 mg/dL Creatinine clearance at least 60 mL/min if creatinine
borderline (1.1-1.6 mg/dL) Other: No active infection No severe malnutrition No
pre-existing grade 2 or worse neurotoxicity No pre-existing edema No senility or psychosis
No other expected difficulties for follow-up including geographic considerations No other
malignancy except: Second testicular primary tumor Treated basocellular and planocellular
skin carcinoma Adequately treated carcinoma in situ of the cervix Not pregnant or nursing
Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease
Characteristics No prior high dose chemotherapy with or without stem cell transplant At
least 3 weeks since chemotherapy and past WBC and platelet nadirs Endocrine therapy: Not
specified Radiotherapy: Not amenable to curative radiotherapy At least 3 weeks since
radiotherapy and recovered Surgery: Not amenable to surgery