Comparison of Conventional Free Breathing CT, 4D CT, and Integrated Active Breath Hold CT Image Acquisition for Lung Cancer
I. Conduct a prospective clinical imaging study to quantify the amount of inter- and
intra-physician contouring variability on four dimensional (4D) CT, active breathing control
(ABC) CT, free breathing CT, and free breathing and ABC cone beam (CB)CT.
II. Quantify the magnitude and distribution of target and organ at risk volume variations
between the different imaging modalities.
III. Determine dosimetric changes related to contouring variations for tumor and normal
Patients undergo conventional free breathing CT, 4D CT, ABC CT, ABC CBCT, and free breathing
CBCT before undergoing radiation therapy.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Amount of inter- and intra-physician contouring variability on 4D CT, ABC CT, free breathing CT, and free breathing and ABC CBCT
A two sided t-test with 5% level of significance will be used.
up to 1 week
Elizabeth Weiss, M.D.
Virginia Commonwealth University
United States: Institutional Review Board
|Virginia Commonwealth University/Massey Cancer Center||Richmond, Virginia 23298|