A Pilot Study of Feasibility of Performing Intravital Microscopy in Melanoma Patients
I. To determine the feasibility of performing intravital microscopy on accessible human
melanoma tumors during their standard course of treatment (i.e., wide local excision). (Part
I. To determine the blood flow velocity of the tumor vessels and tissue penetration of
fluorescein as a marker of tumor vessel permeability. (Part II)
Patients receive fluorescein intravenously (IV) followed by intravital microscopic
observation over 10-15 minutes during excision of the melanoma.
After completion of study treatment, patients are followed up periodically for 6-10 years.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Feasibility of performing intravital microscopy on accessible human melanoma tumors during standard local excision
A successful intravital microscopic observation will include the ability to identify tumor vessels, measure tumor vessel diameters, determine vessel density per 10 x field and visualize fluorescein within the tumor vessels.
Up to 2 months
Roswell Park Cancer Institute
United States: Institutional Review Board
|Roswell Park Cancer Institute||Buffalo, New York 14263|