Inclusion Criteria:

- Adult patients (> 18 yo) with a pathological diagnosis of malignant glioma (WHO
grades III and IV, including all histological subtypes)

- Surgical intervention includes subtotal resection or biopsy with MRI evidence of
residual disease after resection

- Patients with plan to undergo standard chemotherapy and radiation protocols including
a combination of fractionated radiation and temozolomide

- Preoperative Karnofsky performance score (KPS) of > 60

- Willingness of patient and his/her partner to use contraceptive measures for duration
of trial that will include PET studies.

Exclusion Criteria:

- Patient refuses adjunctive therapy

- Pregnancy

- Karnofsky scale < 60

- Inability to undergo MR imaging studies

- Estimated GFR ≤ 60 ml/min (using GFR = 0.85*[140 -
age(y)]*[bodyweight(kg)]/[72*Cr(mg/dl)] for women and GFR = [140 -
age(y)]*[bodyweight(kg)]/[72*Cr(mg/dl)] for men).

- Inability or unwillingness to follow instructions for both PET and MR imaging
sessions.