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N/A
18 Years
N/A
Open (Enrolling)
Both
Immune Reponse To Sepsis, Staphylococcus Aureus Infection

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Trial Information


Inclusion Criteria:



- At least one blood culture positive for S. aureus

- Patients aged ≥18 years

- At least two of four systemic inflammatory response syndrome (SIRS) criteria on the
day of positive blood cultures. SIRS criteria are:

- Body temperature less than 36°C(96.8°F) or greater than 38°C(100.4°F)

- Heart rate greater than 90 beats per minute

- Tachypnea (high respiratory rate), with greater than 20 breaths per minute; or,
an arterial partial pressure of carbon dioxide less than 32 mmHg

- WBC less than 4000 cells/mm³ (4 x 109 cells/L) or greater than 12,000 cells/mm³
(12 x 109 cells/L); or the presence of greater than 10% immature neutrophils
(band forms)

Exclusion Criteria:

- Sequential Organ Failure Assessment (SOFA) score > 12 on day of positive blood
cultures

- Survival expected to be < 7 days from positive blood cultures

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

HLA-DR and cytokines

Outcome Description:

Percent expression of HLA-DR on monocytes will be measured by flow cytometry. Cytokine levels will be measured by ELISA.

Outcome Time Frame:

0-30 days

Safety Issue:

No

Authority:

United States: University of Chicago IRB

Study ID:

13-0491

NCT ID:

NCT01879761

Start Date:

June 2013

Completion Date:

June 2015

Related Keywords:

  • Immune Reponse To Sepsis
  • Staphylococcus Aureus Infection
  • Immunosuppressed
  • Sepsis
  • Staphylococcus Aureus
  • Bacteremia
  • HLA-DR
  • Bacteremia
  • Sepsis
  • Staphylococcal Infections

Name

Location

University of Chicago HospitalChicago, Illinois  60637-1470