Evaluating the Effect of Acetazolamide Administration and Prone Positioning Following Lumbosacral Spinal Surgery in Preventing Cerebro Spinal Fluid Leakage and Collection and Wound Dehiscence in Children.
The purpose of this study is to evaluate the effect of Acetazolamide adminestration and
prone positioning following lumbosacral spinal surgery in preventing cerebro spinal fluid
leakage and collection and wound dehissence in children admited to Children Medical Center
of Tehran since Autumn 2012 to the end of winter of 2014.The study is run under 4 categories
of intervention:
- Group A: Acetazolamide administration for 10 days
- Group B: prone positioning for 10 days
- Group C: Acetazolamide administration+ prone positioning for 10 days
- Group D: no intervention All patients are randomly assigned to these groups and when
the patients faced with any of these complications, the protocol changes to
Acetazolamide administration+ prone positioning and the patient is considered as the
failure of the protocol.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Prevention
Cerebrospinal fluid leakage
leakage of CSF during 1 months following surgery
1month
No
Farideh Nejat, MD
Study Director
Tehran University of Medical Sciences
Iran: Ethics Committee
2137
NCT01867268
October 2012
March 2014
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