A Phase I Study of iPS Cell Generation From Patients With COPD
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, we will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells. Markers of induced pluripotent phenotype will be utilized to assess successful reprogramming.
Dennis A Wigle, MD, PhD
United States: Institutional Review Board
|Mayo Clinic in Rochester||Rochester, Minnesota 55905|