The Effect of the Bioactives of Sea Buckthorn and Bilberry on the Risk of Metabolic Diseases
The aim of the project was to investigate whether it is possible to reduce the risk of
metabolic diseases with supplementing the diet with sea buckthorn berries (Hippophaë
rhamnoides), their bioactive fractions, and bilberries (Vaccinium myrtillus). The study
design was a randomized cross-over clinical trial. The participants were slightly and
moderately overweight female subjects. In total, 110 female volunteers were recruited, and
they followed four different berry diets (bilberry, sea buckthorn, sea buckthorn phenolic
extract and sea buckthorn oil) in a randomized order for 33-35 days. Each intervention was
followed by a wash-out period of 30-39 days. Blood samples were drawn and physical
measurements were performed after each period. Eighty volunteers completed the study.
Different markers of lipid and carbohydrate metabolism and inflammation were measured form
the blood samples.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention
Serum Alanine aminotransferase (ALAT)
Change from beginnig to end of each berry treatment (duration of treatments average 33-35 days)
Jukka-Pekka Suomela, Ph.D.
University of Turku
Finland: Ministry of Social Affairs and Health