Clinical Evaluation of Soft Tissue Detection on MRI, Cone Beam CT and Fan Beam CT and Integration of Functional MR Imaging Into Radiotherapy Planning
I. Establish the technical feasibility of MRI for performing functional soft-tissue
targeting of radiotherapy in the pelvis and thorax. (Group I) II. Acquire clinical MR
imaging data to evaluate image quality tradeoffs and operational parameter settings. (Group
I) III. Validate the selection of MRI technique factors by comparing visibility of soft
tissue structures in MRIs, cone beam (CB)CTs and fan beam (FB)CTs of the same patient.
(Group II) IV. Assess the feasibility of using deformable image registration to map contours
from FBCT to MRI, CBCT to MRI, MRI to MRI and vice versa. (Group II) V. Compare morphologic
and functional changes in target and normal structures, visualized on MRI, CBCT and FBCT
images, in response to radiation therapy and identify opportunities for treatment
adaptation. (Group II)
Patients undergo MRI and FBCT at baseline, within the first 3 weeks of radiotherapy and
between week 4 and 6 of radiotherapy. Patients with lung cancer may undergo 4 dimensional
(4D) CBCT on the same day as the second and third MRI and FBCT.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Technical feasibility of MRI for performing functional soft-tissue targeting of radiotherapy in the pelvis and thorax
Make a preliminary comparison of soft tissue structures delineated from MRI to those identified based on cone beam CT (CBCT) and fan beam CT (FBCT). In addition, variations in the soft tissue identification from repeated MR imaging will be compared to morphological imaging.
up to 6 weeks
Massey Cancer Center
United States: Institutional Review Board
|Virginia Commonwealth University/Massey Cancer Center||Richmond, Virginia 23298|