PARTICIPANT

Inclusion Criteria:

- Participants <19 years of age (eligible until 19th birthday).

- Newly diagnosed, advanced stage, high-risk neuroblastoma defined as one of the
following:

- Children < 1 year with International Neuroblastoma Staging System (INSS) stage
2a, 2b, 3, 4 or 4S disease AND MYCN amplification (>10 copies, or greater than
four-fold increase in MYCN signal as compared to reference signal).

- INSS 2a or 2b disease AND MYCN amplification, regardless of age or additional
biologic features

- INSS stage 3 AND:

1. MYCN amplification (>10 copies, or greater than four-fold increase in MYCN
signal as compared to reference signal, regardless of age or additional
biologic features

2. Age > 18 months (> 547 days) with unfavorable pathology, regardless of MYCN
status

- INSS stage 4 and:

1. MYCN amplification, regardless of age or additional biologic features

2. Age > 18 months (> 547 days) regardless of biologic features

3. Age 12 - 18 months (365 - 547 days) with any of the following three
unfavorable biologic features (MYCN amplification, unfavorable pathology
and/or DNA index =1) or any biologic feature that is indeterminant/unknown

- Children at least 365 days initially diagnosed with: INSS stage 1, 2, 4S who
progressed to a stage 4 without interval chemotherapy.

- Histologic proof of neuroblastoma or positive bone marrow for tumor cells with
increased urine catecholamines.

- Adequate renal and hepatic function (serum creatinine <3 x upper limit of normal for
age, AST< 3 x upper limit of normal).

- No prior therapy, unless an emergency situation requires local tumor treatment
(discuss with principal investigator).

- Written, informed consent according to institutional guidelines.

PARTICIPANT Exclusion Criteria:

- Any evidence, as judged by the investigator, of severe or uncontrolled systemic
disease (e.g., unstable or uncompensated respiratory, cardiac, hepatic, or renal
disease).

- Pregnant or breast feeding (female of child-bearing potential).

- Children with INSS 4 disease, age <18 months with all 3 favorable biologic features
(non-amplified MYCN, favorable pathology and DNA index >1).

DONOR

Inclusion Criteria:

- Potential donor is a biologic parent

- Potential donor is at least 18 years of age.