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40 Years
70 Years
Open (Enrolling)
Gastric Cancer

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Trial Information

Inclusion Criteria:

- Patients consented to spinal anesthesia were enrolled

- Patients aged 40~70 years olds undergoing gastrectomy

- No contraindication of epidural analgesia

- ASA class I and II

- Patients consented to epidural anesthesia were enrolled

Exclusion Criteria:

- Patients with hypovolemia, coagulation disorders, local infection at the site of
operation, history of headache, heart diseases, and history of allergy, chronic
alcohol use or abuse, anemia, congenital heart diseases, bundle block, congestive
heart failure or arrythmias

- patients who had recently received sedative drugs or were under antidepressant
treatment were not included in the study

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care

Outcome Measure:

Heart rate variability analysis

Outcome Description:

Heart rate variability analysis was performed according to the Task Force recommendations. Frequency domain analysis was based on fast Fourier transformation. Power spectrum densities were calculated for low frequencies (LF: 0.04-0.15 Hz) and high frequencies (HF: 0.15-0.4 Hz) informalized units, defined as the LF or HF proportional part of the total power. Baseline and 30min after the injection of the study drug.

Outcome Time Frame:

5min perioids after fluid resuscitation.

Safety Issue:



Korea: Institutional Review Board

Study ID:




Start Date:

February 2012

Completion Date:

June 2013

Related Keywords:

  • Gastric Cancer
  • dexmedetomidine
  • heart rate variability
  • preemptive epidural
  • gastrectomy
  • Stomach Neoplasms