Is Serum Anti-Mullerian Hormone (AMH) Level Associated With Body Weight, Glycemic and Lipidemic Markers in Adolescent Girls With Polycystic Ovaries?
In this study the investigators aimed to investigate whether there is a relation between
body weight and serum anti mullerian hormone levels in adults with polycystic ovary
syndrome. For this purpose the investigators designed a prospective study including three
groups. The diagnosis of polycystic ovary syndrome was made in the presence of ;oligo-
and/or anovulation,clinical and/or biochemical signs of hyperandrogenism and polycystic
ovaries. Clinical hyperandrogenism was defined by the presence of hirsutism , acne, or the
presence of androgenic alopecia , biochemical hyperandrogenemia was defined as a serum level
of total testosterone higher than 2.60 nmol/L, body mass index (BMI) was calculated as
weight in kilograms divided by the square of height in meters. The patients were classified
as obese with BMI ≥ 25 kg/m2 , adolescent patients were diagnosed 2 years after menarche in
order to avoid the misdiagnosis of transitory functional hyperandrogenism and menstrual
disorders during puberty. The all three groups are compared considering their serum AMH
levels,lipid profiles, sex steroids and glycemic analyses.
Observational Model: Case Control, Time Perspective: Prospective
Ovarian reserve, as measured by basal follicle stimulating hormone/anti-Mullerian hormone/antral follicle count
Hüseyin Cengiz, M.D.
Bakirkoy Dr Sadi Konuk Teaching and Research Hospital, Department of Obstetrics and Gynecology
Turkey: Ministry of Health