Inclusion Criteria:

- Psoriatic lean cohort (BMI between 18-24.9 Kg/m2): moderate to severe plaque-type, at
least 5% of BSA

- Psoriatic obese cohort (BMI between 30-40 Kg/m2): moderate to severe plaque-type, at
least 5% of BSA

- Lean/non-psoriatic cohort: BMI between 18-24.9 Kg/m2

- Overweight/obese non-psoriatic cohort: BMI between 30-40 Kg/m2

- Subjects must be 18-65 years of age

Exclusion Criteria:

- Having received any systemic treatment for psoriasis within the last 30 days

- history of bleeding disorder

- weight loss of 10 pounds in the last four weeks

- current smoker

- Known diagnosis of any unrelated autoimmune disease or inflammatory disease ( i.e.
lupus, atopic dermatitis, rheumatoid arthritis).

- Currently taking NSAIDS, aspirin, (if > once a week, stopped <30 days ago). Aspirin
81mg may be permitted if the Framingham Risk Score is < 10

- Having received any anti-inflammatory medication within the last 30 days

- Current use of any anti-coagulants

- LFTs > 2 x upper normal limits

- HIV infection

- Pregnant

- Less than 6 weeks post partum

- history of cardiovascular disease (MI, CHF, CVA)

- Any cancer diagnosis within the last 5 years

- Symptoms of acute illness such as upper respiratory infection, bronchitis,
gastroenteritis, or fever within 3 days of Visit 1

- Any medical, psychological or social condition that, in the opinion of the
Investigator, would jeopardize the health or well-being of the participant during any
study procedures or the integrity of the data

- ingestion of DHA or fish oil within last 90 days

- hypertension as defined as > 140 systolic and > 90 diastolic after 10 minutes of
resting on 2 antihypertensives

- Use of statins within the last 30 days