Inclusion Criteria:

- 1. Age>21 years 2. History of stage I-III breast or colorectal cancer 3. Patient has to
have completed adjuvant or neo-adjuvant Taxane based breast cancer therapy or Oxaliplatin
based colon cancer chemotherapy between one and 24 months prior to registration 4. Signed
informed consent 5. Concomitant biologic, hormonal or radiation therapy are acceptable. 6.
Narcotics, antidepressants or other medications for the treatment of CIPN are permitted,
if patient on a stable dose for at least one month prior to enrollment.

7. Pain as defined by BPI worst pain greater than or equal to a 5 out of 10. 8. CIPN as
defined by experiencing neuropathy (numbness, tingling, thermal hyperalgesia or cold
allodynia) in the hands and feet frequently or most of the time in the past seven days.

Exclusion Criteria:

Previous treatment with topical menthol (menthol/methylsalicylate products like BenGay,
Aspercreme, or Icy Hot) of any concentration within the previous 3 months 2. Known
diabetic neuropathy 3. Severe concomitant illnesses 4. Known allergy or
preexisting skin disease which prohibits use of menthol 5. Any topical treatment for
neuropathy or other serious skin condition on the hands or feet.

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