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Low Tube Voltage Computed Tomographic (CT) Urography Using Low Concentration Iodine Contrast Agent: a Comparison Study With Conventional CT Urography


N/A
20 Years
70 Years
Open (Enrolling)
Both
Exposure to Medical Diagnostic Radiation

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Trial Information

Low Tube Voltage Computed Tomographic (CT) Urography Using Low Concentration Iodine Contrast Agent: a Comparison Study With Conventional CT Urography


Computed Tomographic (CT) urography is the best imaging modality to evaluate obstructing
lesions of urinary tract such as urinary stone, tumor and inflammatory lesion. It is needed
that CT urography should have the high contrast between target lesion described as filling
defect and adjacent contrast filled urinary tract. For the implementation of high contras,
conventional CT urography has been performed with higher voltage and higher concentrated CT
contrast than another CT protocols. The higher voltage results in the more radiation
exposure. And the intravenous injection of higher concentrated CT contrast results in the
increase of the prevalence of contrast induced nephrotoxicity.

The purpose of our study is to compare images of CT urography performed by low voltage and
low concentrated iodine CT contrast with them of conventional CT urography.


Inclusion Criteria:



- Patients to perform Computed Tomographic (CT) urography

- Patients without diminish of renal function (serum creatinine: more than 1.4 mg/dl &
glomerular filtration rate: more than 34 mL/min/1.73 m2)

Exclusion Criteria:

- patients to have operations and/or injuries of urinary system

- patients to have the histories of anaphylaxis or allergic reaction about intravenous
iodine contrast material

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Diagnostic

Outcome Measure:

Measurement of Radiation Dose

Outcome Time Frame:

The day of admission (within 24hours)

Safety Issue:

No

Principal Investigator

Jeong Yeon Cho, Professor

Investigator Role:

Principal Investigator

Investigator Affiliation:

Departement of Radiology, Seoul National University Hospital

Authority:

Korea: Institutional Review Board

Study ID:

SeoulNUH-rad

NCT ID:

NCT01855204

Start Date:

April 2013

Completion Date:

March 2014

Related Keywords:

  • Exposure to Medical Diagnostic Radiation
  • Computed Tomography, Spiral
  • Urography
  • Radiation dosage
  • Contrast media

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