Inclusion Criteria

Inclusion Criteria

- Joined the study voluntarily and signed informed consent form;

- Age 18-75

.Presence of at least one index lesion measurable by CT scan or MRI

- recurrence/metastasis of Esophageal carcinoma or gastroesophageal cancer confirmed by
pathology

- No radiotherapy, chemotherapy or other treatments prior to enrollment

- PS ECOG 0-1

- Life expectancy of more than 3 months

- ANC≥2×109/L，PLT≥100×109/L，Hb≥90g/L

- Cr≤1.0×UNL

- TBIL≤1.25×UNL； ALT/AST≤2.5×UNL，with hepatic metastases
ALT/AST≤5.0×UNL；AKP≤2.5×UNL

Exclusion Criteria:

- there is radical cure of the cancer

- uncontrolled chronic diarrhea and esophageal obstruction

- Neurological or mental abnormalities Influence of cognitive ability include
central nervous system metastases

- Severe complication(s), e.g.,uncontrolled active infection,myocardial
infarction,hypertension,arrhythmia,stenocardia

- Patient who has metastasis except cured skin basal cell carcinoma and carcinoma
in situ of cervix

- accept other antitumor therapy •Female patients during their pregnant and lactation
period, or patients without contraception