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Endometrial Injury May Increase the Clinical Pregnancy Rate in Normoresponders Underwent Long Agonist Protocol Intracytoplasmic Sperm Injection Cycles With Single Embryo Transfer


N/A
18 Years
35 Years
Not Enrolling
Female
Primary Infertility

Thank you

Trial Information

Endometrial Injury May Increase the Clinical Pregnancy Rate in Normoresponders Underwent Long Agonist Protocol Intracytoplasmic Sperm Injection Cycles With Single Embryo Transfer


Endometrial injury means endometrial biopsy on day 3 of menstrual cycle following down
regulation in an IVF patient.


Inclusion Criteria:



- woman age under 35 years

- history of primary infertility

- normoresponder (antral follicle count 5-10 in one ovary in early follicular phase

- having grade I or II embryos for transfer

- agree to undergo endometrial biopsy during the COH cycle. All patients were
stimulated with luteal phase long protocol.

Exclusion Criteria:

- endocrinopathies (including diabetes mellitus, hyperprolactinemia, Cushing's disease,
and congenital adrenal hyperplasia), any systemic disease, collagen disorder,
hypercholesterolemia, sickle cell anemia, and a history of neoplasm; -high risk for
or history of OHSS

- using any concurrent medication (e.g., insulin-sensitizing drugs, and GnRH
antagonists)

- patients who did not proceed to follicle retrieval

- severe male infertility requiring TESA/TESA

- mullerian tract anomalies

- a history of endometrial instrumentation or surgery within a month of the study

- not agree to undergo endometrial biopsy during the COH cycle.

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Clinical pregnancy rate

Outcome Time Frame:

up to 6 months

Safety Issue:

No

Principal Investigator

Suleyman Guven

Investigator Role:

Principal Investigator

Investigator Affiliation:

Karadeniz Technical University

Authority:

Turkey: Ethics Committee

Study ID:

2011/20

NCT ID:

NCT01851876

Start Date:

September 2010

Completion Date:

April 2011

Related Keywords:

  • Primary Infertility
  • Infertility
  • Adenoma

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