Collection of Saliva From Healthy Volunteers for Research
- Chronic graft-versus-host disease (cGVHD) is a severe immunological complication that
occurs after allogeneic hematopoietic stem cell transplantation (HSCT). Although oral
cGVHD occurs in > 25% of cGVHD patients and leads to decreased quality of life, its
etiology is poorly understood.
- The primary objective of the present protocol is to enroll normal volunteers who will
contribute a saliva sample in order to compare its characteristics with those of
patients with and without chronic GVHD after allogeneic HSCT. The normal control saliva
samples will provide a standard of comparison for patient saliva samples from ongoing
NCI cGVHDrelated protocols.
-To collect approximately 5 ml of saliva from healthy volunteers as needed to support
- Healthy individuals (including employees) all racial/ethnic groups, aged 18 years or
- Volunteers must be willing to undergo saliva collection.
- No active illnesses, immunodeficiency, history of opportunistic infection, autoimmune
disease, immunosuppressive medications or prior organ, bone marrow or peripheral blood
stem cell transplant.
- Ability of subject to understand and provide written informed consent.
- Phase I of the study will be restricted to males, age 30-70 years
- Healthy volunteers will be offered the opportunity to participate in this protocol.
- A basic clinical dental assessment will be done.
- Saliva samples will be collected from the consenting subject.
- Protein assays will be performed on the collected saliva sample.
Time Perspective: Prospective
Collect 5 ml of saliva from healthy volunteers
Steven Z Pavletic, M.D.
National Cancer Institute (NCI)
United States: Federal Government
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Bethesda, Maryland 20892|