Inclusion Criteria:

- Age of at least 18 years.

- Confirmation of germ cell tumor histology based on pathologic review at the study
site.

- Presence of a CD30 positive embryonal carcinoma component.

- Unequivocal progression of measurable disease.

- A minimum of 2 and a maximum of 3 platinum-based chemotherapy lines for metastatic
disease EXCEPT for primary mediastinal germ cell tumors where failure of first-line
chemotherapy only is accepted.

- Prior high dose chemotherapy with hematopoietic stem cell rescue is allowed.

Exclusion Criteria:

- Failure to meet any of the above inclusion criteria.

- Patients with late-relapse (defined as relapse occurring after at least 2 years from
the date of completion of the last chemotherapy regimen) whose disease is completely
surgically resectable (and for whom initial surgical extirpation is recommended) are
ineligible. Patients with unresectable late disease relapse are eligible.