Pulmonary Tumor Motion Reduction and Improved Breathing Reproducibility by Prone Patient Positioning in Radiation Therapy
I. Quantify the three-dimensional tumor and normal tissue (thoracic and abdominal) motion,
deformation and volume changes with the respiratory cycle during imaging in prone vs. supine
II. Quantify the three-dimensional tumor and normal tissue (thoracic and abdominal) motion,
deformation and volume changes with the respiratory cycle and alterations thereof during a
Patients undergo one conventional computed tomography (CT) scan and one 4 dimensional CT (4D
CT) scan in both supine and prone positioning before undergoing radiation therapy.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Consistency of the respiratory pattern, quantified by the cycle-to-cycle variation in the respiration trace during imaging in prone vs. supine positioning
During the 4D CT patient respiration trace will be recorded using the RPM optical tracking device. The average and standard deviation of the amplitude, period, end of inhalation position, and end of exhalation position of the respiration trace will be calculated. Paired t tests and F tests will be used to evaluate differences between these quantities for supine and prone positioning.
up to 90 days
Mihaela Rosu, Ph.D.
Virginia Commonwealth University
United States: Institutional Review Board
|Virginia Commonwealth University, Massey Cancer Center||Richmond, Virginia 23298|