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Evaluating the Expression Levels of microRNA-10b in Patients With Gliomas

18 Years
Open (Enrolling)
Astrocytoma, Oligodendroglioma, Oligoastrocytoma, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Anaplastic Oligoastrocytoma, Glioblastoma, Brain Tumors, Brain Cancer

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Trial Information

Evaluating the Expression Levels of microRNA-10b in Patients With Gliomas

Inclusion Criteria

Inclusion/Exclusion Criteria:

- 18 years of age

- Brain tumor(s) to be resected for clinical reasons.

- Histological pathology confirmation that tumor is of glial origin, WHO Grade II, III
or IV.

- Adequate tissue available for processing as determined by Pathology.

- Adequate decision making ability to review, discuss and sign a consent form to allow
their tumor samples to be used for future human brain tumor biology laboratory
research. Determination of capacity to consent is made by one of the co-investigators
based on clinical assessment.

- Patients opting for the standard treatment regimen for their disease as well as
ongoing clinical trials will be are eligible to participate in this study. Standard
care for newly-diagnosed glioblastomas typically consists of surgical resection
followed by radiotherapy with concomitant temozolomide, followed by adjuvant
temozolomide chemotherapy.

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Overall Survival

Outcome Description:

Patients will be followed for survival every 12 weeks +/- 1 week.

Outcome Time Frame:

24 months

Safety Issue:


Principal Investigator

Arti B Gaur, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dartmouth-Hitchcock Medical Center


United States: Institutional Review Board

Study ID:




Start Date:

May 2013

Completion Date:

December 2015

Related Keywords:

  • Astrocytoma
  • Oligodendroglioma
  • Oligoastrocytoma
  • Anaplastic Astrocytoma
  • Anaplastic Oligodendroglioma
  • Anaplastic Oligoastrocytoma
  • Glioblastoma
  • Brain Tumors
  • Brain Cancer
  • glioblastoma
  • miRNA
  • GBM
  • astrocytoma
  • Astrocytoma
  • Brain Neoplasms
  • Glioblastoma
  • Oligodendroglioma



Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire  03756