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Anatomical Clinical Correlations. Neuropsychological and Brain Medical Imaging Study in Brain Damaged Subjects.

18 Years
80 Years
Open (Enrolling)
Cerebrovascular Disorders, Brain Lesions, Degenerative Diseases, Developmental Pathology

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Trial Information

Anatomical Clinical Correlations. Neuropsychological and Brain Medical Imaging Study in Brain Damaged Subjects.

Inclusion Criteria:

- age between 18 and 80 years

- french language

- effective contraception for women during the study

- informed consent

- no alcohol intake the day before the exam

- for patients only, focal cerebral lesion (stroke, malformation, tumor, inflammatory,
infectious, traumatic), neonatal pathology or degenerative disease with cognitive

Exclusion Criteria:

- for healthy volunteers: previous neurological history (except non complicated
migraine), previous psychiatric history (except depression with good evolution or
anxiety with maximum one anxiolytic treatment), or severe cranial traumatism

- for patients: vigilance disorders, severe depression or anxiety.

- for both: psychotropic medication other than a hypnotic or an anxiolytic at low doses
without dose modification for at least one month, severe visual or auditory
impairment, patient without judicial or administrative liberty, measure of legal
protection or no capable to express their consent, pregnancy or breastfeeding,
contraindication for MRI, participation in another trial or former involvement in
another trial within one month

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Outcome Measure:

Cognitive deficit

Outcome Description:

The cognitive deficit of interest will depend on the localization of the brain lesion. The outcome measure could be a standardized neuropsychological test or an experimental test specifically elaborated for this protocol.

Outcome Time Frame:

3 to 6 months

Safety Issue:


Principal Investigator

Olivier MARTINAUD, Doctor

Investigator Role:

Principal Investigator

Investigator Affiliation:

service de Neurologie


France: Agence Nationale de Sécurité du Médicament et des produits de santé

Study ID:




Start Date:

May 2013

Completion Date:

January 2019

Related Keywords:

  • Cerebrovascular Disorders
  • Brain Lesions
  • Degenerative Diseases
  • Developmental Pathology
  • neuropsychological Study
  • brain Imaging
  • Cerebrovascular Disorders