Inclusion Criteria:

- Patient must be ≥ 18 years of age.

- Histologically proven primary colorectal carcinoma

- Patient is clinical stage IV (AJCC 7th Edition)

- Patient exhibits 1-4 liver metastasis

- Liver is only site of metastasis

- Chemotherapy administered prior to enrollment

- Life expectancy > 3 months

- At least 4 weeks from any chemotherapy

- CBC, platelets, LFTs, PTT all within normal institutional limits

- Patient's albumin level is >3gm/dl.

- Negative pregnancy test within 72 hours of study entry for women of childbearing
potential

- ECOG performance status 0-1

Exclusion Criteria:

- Prior radiotherapy to the liver

- Hepato renal syndrome

- Malignant ascites

- Chemotherapy for a malignancy in the last 5 years

- Inflammatory Bowel disease