Inclusion Criteria:

- Aged 18-65 years

- Liver failure

- Negative pregnancy test (female patients in fertile age)

- Written consent

- HBsAg positive

- TB≥171 μmol/L or ascend ≥17.1 μmol/L/per day,

- INR≥1.5 or 20%＜PTA≤40%

- 17≤MELD score≤30

Exclusion Criteria:

- Hepatocellular carcinoma or other malignancies

- Severe problems in other vital organs(e.g.the heart,renal or lungs)

- Pregnant or lactating women

- Severe bacteria infection

- Anticipated with difficulty of follow-up observation

- Liver failure caused by other reasons, such as autoimmune diseases, alcohol, drug and
so on

- Other candidates who are judged to be not applicable to this study by doctors