Assessment of Helical Tomotherapy Radiotherapy (54 Gy) Followed by Surgery in Retro-peritoneal Liposarcoma
Retro peritoneal liposarcomas are rare (less than 15% of sarcomas) whose prognosis is
locoregional. In the treatment of retroperitoneal liposarcomas main prognostic factor is the
quality of the surgical resection. The effect of radiotherapy combined with surgery is
uncertain and until now limited perhaps because of limited prescribed doses (of the order of
45Gy to 50Gy) due to high risk of organ toxicity nearby.
Two elements can overcome these difficulties:
- Preoperative radiotherapy made rather than Postoperatively, the tumor in place back
the gastrointestinal tract and reducing toxicity,
- The contribution of conformal radiotherapy techniques with intensity modulation (IMRT).
The helical tomotherapy is an innovative equipment radiotherapy to make conformational
radiotherapy modulation intensity and is particularly suitable for irradiations
precision (imaging mode associated with daily scanner) in large complex volumes.
Increasing doses (increase of the prescribed dose to 54 Gy, thus potentially curative),
the helical tomotherapy should allow to improve the efficacy of radiotherapy.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
disease-free survival Evaluation of the efficacy of the combination with radio-surgery helical tomotherapy irradiation to a dose of radiation of 54 Gy in patients with retroperitoneal liposarcoma of operable.
Evaluation of the efficacy of the combination with radio-surgery helical tomotherapy irradiation to a dose of radiation of 54 Gy in patients with retroperitoneal liposarcoma of operable. The effectiveness will be evaluated in terms of disease-free survival Local 3 years
08/2013 (3 years)
KANTOR Guy, PU-PH
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)