Inclusion Criteria:

1. ≥20 years of age

2. Histologically or cytologically confirmed unresectable, recurrent or metastatic
gastric cancer

3. Failure of a first line therapy with fluoropyrimidine +/- platinum for metastatic or
recurrent disease.(Adjuvant chemotherapy is not considered as a first line
chemotherapy unless recurrence developed within 6 months of completion of adjuvant
therapy.)

4. Adequate bone marrow, liver and renal functions

5. INR ≤ 2.0

6. ECOG performance status ≤ 2

7. Neuropathy grade ≤ 1

8. Life expectancy of at least 3 months

9. Measurable lesion according to RECIST version 1.1 on CT scan

10. Written informed consent

11. Patients of child bearing age have to agree to the usage of adequate contraception
from before the registration to the study, during the participation period and 90
days after the end of treatment. Female of child bearing age has to show negative for
urin pregnancy test within 7 days from beginning of the start of administration.
Amenorrhea status has to be sustained for at least 12 months to be considered
non-pregnant in case of postmenstrual women.

Exclusion Criteria:

1. Major infectious disease, neurological disorder, or bowel obstruction.

2. Patients with CNS metastases(confirmed through brain imaging if there are symptoms)

3. Patient diagnosed with another cancer type (except non-melanoma skin cancer, cervical
cancer, or any other cancer that did not recur or metastasized for more than 5 years
and considered as complete remission can be registered)

4. Patient who received radiation therapy within past 2 weeks or who had major surgery
including organ resection within past 4 weeks from random assignment date

5. Patient with the history of failure to the taxane chemotherapy

6. Patient who need chronic concomitant use of P glycoprotein, immune suppressor, proton
pump inhibitor, or H2-receptor antagonist during the period of clinical trial

7. Chronic treatment using steroid (except oral, local injection, or for externally
applied) or other immune suppressor

8. Patient with myocardial infarction, congestive heart failure, arrhythmia showing
abrupt change in the ECG, severe or unstable angina, or other serious heart disease

9. Patient with other serious internal disease (chronic obstructive or chronic
inhibitory lung disease including shortness of breathe at rest due to all reasons,
uncontrollable diabetes and hypertension)

10. History of abuse of a drug or alcohol within 3 months

11. Lactating or pregnant women, or patient (or spouse) who has no intension of using, or
cannot use very effective mean of contraception

12. Patient who has or is suspected to have problem in bile acid secretion

13. Patient with active gastrointestinal bleeding, or taking oral anti- vitamine K (With
the exception of low dose of Warfarin and acetylsalicylic acide when INR≤2.0)

14. History of serious hypersensitive reaction to the main ingredient or the excipient of
the investigational drug

15. History of being seropositive for HIV (HIV test is not a prerequisite).

16. Patients with gastrointestinal dysfunction or on enteral feeding

17. Other patients who are deemed inadequate to participate in the clinical trial by the
investigator