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Effects of High Dietary Fiber Supplementation on Uremic Retention Molecules and Inflammation in Diabetic CKD


N/A
18 Years
90 Years
Open (Enrolling)
Both
Kidney Disease

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Trial Information

Effects of High Dietary Fiber Supplementation on Uremic Retention Molecules and Inflammation in Diabetic CKD


Inclusion Criteria:



1. Adults aged >18 years old and older.

2. Patients with or without diabetes and Stage 1 or 2 CKD (eGFR > 60 mL/min/1.73 m2)
with urine dipstick positive for protein or urinary albumin/ creatinine > 30 mg/g of
creatinine, or

3. Stage 3 or 4 CKD (eGFR < 60 to 15 mL/min/1.73 m2).

Exclusion Criteria:

1. Pregnant women,

2. Prisoners,

3. Bowel obstruction,

4. Enrolled in other interventional studies.

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Outcome Measure:

Uremic Toxins and inflammation in CKD

Outcome Description:

1. To examine whether the higher serum levels of p-cresyl sulfate and indoxyl sulfate partly explain the increased serum levels of hsCRP, IL-6 and TNF-α in stage 3-4 CKD compared to stage 1-2 CKD.

Outcome Time Frame:

baseline

Safety Issue:

No

Principal Investigator

Nestor Almeida, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Utah

Authority:

Faculty Sponsor: Srinivasan Beddhu

Study ID:

IRB_00052609

NCT ID:

NCT01838330

Start Date:

June 2012

Completion Date:

Related Keywords:

  • Kidney Disease
  • Kidney Disease
  • Fiber
  • Dietary Intervention
  • Inflammation
  • Kidney Diseases
  • Renal Insufficiency, Chronic

Name

Location
University of Utah nephrology clinics, the internal medicine and endocrinology clinics Salt Lake City, Utah  84112