Inclusion Criteria:

1. Signed informed consent form

2. Performance Status- Eastern Cooperative Oncology Group (ECOG) 0-2;

3. Histologically or cytologically confirmed gastric cancer;

4. The first-line chemotherapy failure (required containing 5-fluorouracil)

5. At least have one measurable disease(according to RECIST, Response Evaluation
Criteria in Solid Tumors )

6. Life expectancy of at least 3 months;

Exclusion Criteria:

1. Received any prior treatment including Raltitrexed;

2. Active or uncontrolled infection;

3. Concurrent treatment with an investigational agent or participation in another
therapeutic clinical trial;

4. Pregnant or lactating women.