Inclusion Criteria:

Each patient must meet all of the following inclusion criteria to be enrolled in the
study:

- diagnosis of relapsed or progressed disease pretreated with no more than three prior
chemotherapy regimen and/or immunochemotherapy;

- age > 18 years;

- Eastern Cooperative Oncology Group (ECOG) performance status 0-2;

- no evidence of transformation to a high grade lymphoma;

- active disease requiring treatment;

- two-dimensionally measurable disease in at least one site or evaluable disease;

- Velcade® naïve;

- life expectancy >6 months;

- no prior chemotherapy, immunotherapy or radiotherapy in the last 8 weeks;

- adequate renal function (calculated or measured creatinine clearance > 30 mL/minute),
liver function aspartate aminotransferase (ASAT)/alanine aminotransferase (ALAT) <
3.0 x upper normal, total bilirubin < 2,5 x upper normal), unless due to lymphoma
involvement;

- left ventricular ejection fraction (LVEF) > 50%;

- no evidence of active opportunistic infections;

- HbsAg, and hepatitis C virus (HCV) e HIV negativity. Positive serology for hepatitis
B virus (HBV) and HCV admitted only upon negativity of HBV-DNA and HCV-RNA tests;

- no serious medical illness likely to interfere with participation in this clinically
study;

- voluntary Written Informed Consent before performance of any study-related
procedures;

- patient is able (i.e. sufficiently fluent) and willing to complete the quality of
life questionnaires in validated translations. Inability (illiteracy, loss of sight,
or other equivalent reason) to complete the questionnaires will not make the patient
ineligible for the study. However, ability but unwillingness to complete the
questionnaires will make the patient ineligible; 17. female subject is either
post-menopausal or surgically sterilized or willing to use an acceptable method of
birth control (ie, a hormonal contraceptive, intra-uterine device, diaphragm with
spermicide, condom with spermicide, or abstinence) for the duration of the study.
Male subject agrees to use an acceptable method for contraception for the duration of
the study;

Exclusion Criteria:

- prior diagnosis of neoplasm (except than follicular lymphoma) within 5 years, except
cervical intraepithelial neoplasia type 1 (CIN1) or localized non melanomatous skin
cancer;

- refractory disease (non responding patient to previous treatment);

- other investigational drug within 28 days before enrollment;

- evidence of symptomatic central nervous system (CNS) disease;

- severe impairment of bone marrow function (Absolute Neutrophil Count (ANC) < 1.5 x
109/L, platelet (PLT) < 50 x109/L within 14 days before enrollment), unless due to
lymphoma involvement;

- evidence of ≥ grade 2 neuropathy within 14 days before enrollment;

- known hypersensitivity to bortezomib, boron or mannitol;

- known hypersensitivity or anaphylactic reactions to murine antibodies or proteins;

- uncontrolled or severe cardiovascular disease including myocardial infarction within
6 months of enrollment, New York Heart Association (NYHA) Class III or IV heart
failure (Attachment 7, NYHA Classification of Cardiac Disease), uncontrolled angina,
clinically significant pericardial disease, or cardiac amyloidosis;

- pregnant or lactating status, confirmation that the subject is no pregnant must be
established by a negative serum human chorionic gonadotropin (hCG) pregnancy test
result obtained during screening. Pregnancy testing is not required for post
menopausal or surgically sterilized women;

- any psychological, familial, sociological or geographical condition potentially
hampering compliance with the study protocol and follow up schedule; those conditions
should be discussed with the patient before registration in the trial.