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CTP (Computed Tomography Perfusion) Imaging of Lung Cancer

18 Years
Open (Enrolling)
Non Small Cell Lung Cancer

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Trial Information

CTP (Computed Tomography Perfusion) Imaging of Lung Cancer

This is an experimental study of CT perfusion (CTP) imaging in subjects with non-small cell
lung cancer. The objectives of this study are to demonstrate the feasibility of CT blood
flow measurements in lung cancer, to develop a foundation for the use of CT blood flow
measurements in lung cancer to assess the response to treatment, and to develop an optimized
CTP imaging protocol for evaluating blood flow in solid body tumors. In this study, tumor
blood flow will be evaluated at baseline and follow-up routine CT examinations of patients
with non-small cell lung cancer, and the response of tumor blood flow will be recorded as a
secondary endpoint. This research study will entail two study visits - one required and one
optional - which will coincide with regularly scheduled standard of care CT scans.

Inclusion Criteria:

adult patients with non small cell lung cancer who receive, or are considered for,
systemic therapy

Exclusion Criteria:

renal failure pregnancy known contrast allergy


Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Yield of conducting CTP studies

Outcome Description:

Yield is determined as the percentage of assessable CTP studies, relative to all performed studies

Outcome Time Frame:

2 years

Safety Issue:


Principal Investigator

Friedrich Knollmann, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Univeristy of California, Davis


United States: Institutional Review Board

Study ID:




Start Date:

March 2013

Completion Date:

December 2015

Related Keywords:

  • Non Small Cell Lung Cancer
  • lung cancer
  • computed tomography
  • blood flow
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms



University of California, Davis Medical Center Sacramento, California