Know Cancer

forgot password

Effects of High Intensity Interval Exercise on Inflammation and Endothelial Function in Children & Adolescents With Obesity

13 Years
17 Years
Open (Enrolling)
Childhood Obesity, Inflammation

Thank you

Trial Information

Effects of High Intensity Interval Exercise on Inflammation and Endothelial Function in Children & Adolescents With Obesity

Obesity, even in children, is generally accompanied by a state of chronic inflammation. To
combat childhood obesity, clinicians and scientists recommend lifestyle interventions that
include increased physical activity and exercise in an attempt to promote weight loss and,
consequently, decrease comorbidities associated with excess adiposity. More importantly, it
appears that the influence of regular exercise may offer children with obesity a multitude
of health benefits, independent of weight loss. However, the intensity of exercise required
to elicit significant health benefits is still unclear. Therefore, the aim of the present
project is to study the influence of high intensity interval exercise (HIIE) on the existing
inflammatory state found in obesity. Specifically, the proposed project will examine
endothelial function and markers of inflammation, such as TNFa, IL-6, hsCRP, and
adiponectin, in children with obesity before and after an exercise intervention. The data
will then be used to determine if changes in these values differ in magnitude based on the
intensity of exercise. Children with obesity will be randomized into either moderate
exercise or HIIE groups, and attend sessions 3 times per week for 6 weeks. The moderate
group will cycle continuously for 30 minutes at 65%-70% of maximal heart rate and the HIIE
group will perform ten, 2-minute bouts at 90%-95% of maximal heart rate. Outcome measures of
body composition, aerobic capacity, blood lipids, glucose metabolism, endothelial function,
and inflammation will be measured pre- and post-intervention. Results may help in
establishing exercise protocols not only for children with obesity, but also other
inflammatory diseases such as diabetes, cancer, and arthritis.

Inclusion Criteria:

- 13-17 years old

- obesity (defined as as BMI≥ 95th percentile for age and sex as defined by the Centers
for Disease Control

Exclusion Criteria:

- active participation in ≥30 minutes of vigorous exercise more than 2 days per week

- participation in an organized combined diet/exercise weight loss intervention

- acute inflammatory disease or febrile illness

- recent trauma or injury

- asthma requiring steroid use or that has resulted in hospitalization within 3 months
prior to enrollment

- chronic disease known to affect inflammation (e.g. lupus)

- any renal, heart, or liver disease

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Inflammation and endothelial function measured via forearm vascular resistance (FVR) and blood markers including tumor necrosis factor alpha (TNF-a), interleukin-6 (IL-6), adiponectin, high sensitivity C-reactive protein (hsCRP), and endothelin 1.

Outcome Description:

The primary outcomes are the percent change in FVR and in inflammatory markers (hsCRP, IL-6, TNF-α, and adiponectin) from pre- to post-intervention in both groups.

Outcome Time Frame:

Within one month pre and one month post-intervention

Safety Issue:


Principal Investigator

Ihuoma Eneli, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Nationwide Children's Hospital


United States: Institutional Review Board

Study ID:




Start Date:

September 2012

Completion Date:

April 2013

Related Keywords:

  • Childhood Obesity
  • Inflammation
  • Childhood obesity
  • Inflammation
  • Endothelial function
  • Exercise
  • Inflammation
  • Obesity



The Ohio State University Columbus, Ohio  43210