Inclusion Criteria:

- FIGO stage: Ⅰ, endometrial carcinoma;

- Female, Chinese women;

- Initial treatment is staging surgery;

- Pathological diagnosis: Endometrial adenocarcinoma;

- Pathologic examination and meet the following one of the indications of adjuvant
therapy: ① histopathological grading in poorly differentiated: G3; ② ≥50% myometrial
invasion; ③ vascular space involvement;

- No prior treatment;

- Provide written informed consent.

Exclusion Criteria:

- Unable to receive surgery and/or unsuitable for radiotherapy or chemotherapy;

- Family history of ovarian cancer;

- Suffering from other malignancies;

- Concurrently participating in other clinical trials;

- Unable or unwilling to sign informed consents;

- Unable or unwilling to abide by protocol.