Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation
This is an observational study to collect health data from long-term survivors of Hodgkin
lymphoma (HL). Data will be collected once at participant enrollment. The long-term
effects of thoracic radiation therapy (TRT) given earlier as part of the treatment for HL
will be examined in long-term survivors and compared to health data collected from normal
HL survivors who were treated at St. Jude Children's Research Hospital (SJCRH) with TRT will
be recruited to complete a comprehensive neurocognitive evaluation, brain MRI/MRA, a
clinical neurological exam, peripheral pulse contour analysis, non-invasive central blood
pressure monitoring, cardiopulmonary exercise testing, and serum biomarkers related to
cardiac disease. As part of their standard St. Jude LIFE protocol evaluation, they also
complete an echocardiogram, pulmonary function tests and questionnaires designed to evaluate
broad health, psychological, socioeconomic and environmental factors that impact everyday
A comparison sample of healthy individuals, frequency-matched on age, sex and race will also
be recruited. The comparison group will complete the comprehensive neurocognitive
evaluation, brain MRI/MRA, clinical neurological exam, pulse contour analysis, non-invasive
central blood pressure monitoring, and cardiopulmonary exercise testing. Through the St.
Jude LIFE protocol, the comparison sample will also complete an echocardiogram, pulmonary
function tests and questionnaires designed to evaluate broad health, psychological,
socioeconomic and environmental factors that impact everyday life.
Observational Model: Case Control
Neurocognitive measures of sustained attention and memory between HL survivor group and control group.
To evaluate brain integrity in adult survivors of childhood cancer treated with thoracic radiation therapy. Two-sided two-sample t test will be conducted to compare the difference of neurocognitive impairment in area of sustained attention and memory in the HL survivors and matched controls.
Once, at or near enrollment
Kevin Krull, PhD
St. Jude Children's Research Hospital
United States: Institutional Review Board
|St. Jude Children's Research Hospital||Memphis, Tennessee 38105-2794|